Sekikawa Yoshiyuki, Hongo Igen
Infectious Diseases, Musashino Red Cross Hospital, Musashino, Tokyo, Japan.
BMJ Case Rep. 2017 Sep 28;2017:bcr-2017-221869. doi: 10.1136/bcr-2017-221869.
Approximately 1%-10% of patients with HIV infection have been reported to have salivary gland enlargement. Parotid swelling in patients with HIV is often associated with salivary gland disease, including benign lymphoepithelial cysts (BLECs). The presence of BLEC can serve as an indicator of HIV infection, and the diagnosis of HIV-associated BLEC is usually based on clinical course, HIV confirmatory blood testing, such as western blot or viral detection, and imaging studies, but not on biopsies or immunostaining. To exclude other diseases such as tuberculosis and malignant lymphoma and to further improve the diagnostic accuracy of BLEC, the detection of the HIV-1 p24 antigen by immunohistochemistry is a useful diagnostic method. We report a case of a 65-year-old Japanese man with swelling of the parotid glands and HIV-associated BLEC confirmed via HIV-1 p24 immunohistochemical staining.
据报道，约1%-10%的HIV感染患者会出现唾液腺肿大。HIV患者的腮腺肿大通常与唾液腺疾病有关，包括良性淋巴上皮囊肿（BLEC）。BLEC的存在可作为HIV感染的一个指标，HIV相关BLEC的诊断通常基于临床病程、HIV确证性血液检测（如免疫印迹法或病毒检测）以及影像学检查，而非活检或免疫染色。为排除其他疾病，如结核病和恶性淋巴瘤，并进一步提高BLEC的诊断准确性，通过免疫组织化学检测HIV-1 p24抗原是一种有用的诊断方法。我们报告一例65岁日本男性腮腺肿大病例，经HIV-1 p24免疫组织化学染色确诊为HIV相关BLEC。
