Lin Kimberly C, Park Hyun Woo, Guan Kun-Liang
Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Republic of Korea.
Trends Biochem Sci. 2017 Nov;42(11):862-872. doi: 10.1016/j.tibs.2017.09.003. Epub 2017 Sep 27.
The TEAD transcription factor family is best known for transcriptional output of the Hippo signaling pathway and has been implicated in processes such as development, cell growth and proliferation, tissue homeostasis, and regeneration. Our understanding of the functional importance of TEADs has increased dramatically since its initial discovery three decades ago. The majority of our knowledge of TEADs is in the context of Hippo signaling as nuclear DNA-binding proteins passively activated by Yes-associated protein (YAP) and transcriptional activator with PDZ-binding domain (TAZ), transcription coactivators downstream of the Hippo pathway. However, recent studies suggest that TEAD itself is actively regulated. Here, we highlight evidence demonstrating Hippo-independent regulation of TEADs and the potential impacts these studies may have on new cancer therapeutics.
TEAD转录因子家族因参与Hippo信号通路的转录输出而最为人所知，并与发育、细胞生长和增殖、组织稳态及再生等过程相关。自三十年前首次发现TEAD以来，我们对其功能重要性的理解有了显著提升。我们对TEAD的大部分了解是在Hippo信号通路的背景下，即作为被Yes相关蛋白（YAP）和含PDZ结合结构域的转录激活因子（TAZ）被动激活的核DNA结合蛋白，它们是Hippo通路下游的转录共激活因子。然而，最近的研究表明TEAD本身受到主动调控。在此，我们着重介绍一些证据，这些证据证明了对TEAD的非Hippo依赖性调控以及这些研究可能对新型癌症治疗产生的潜在影响。
