Psathas Giannos, Zarokosta Maria, Zoulamoglou Menelaos, Chrysikos Dimosthenis, Thivaios Ioannis, Kaklamanos Ioannis, Birbas Konstantinos, Mariolis-Sapsakos Theodoros
University Department of Surgery, General and Oncologic Hospital of Kifissia "Agii Anargiri", Athens, Greece.
University Department of Surgery, General and Oncologic Hospital of Kifissia "Agii Anargiri", Athens, Greece; Anatomy and Histology Laboratory, Nursing School, University of Athens, Greece.
Int J Surg Case Rep. 2017;40:105-108. doi: 10.1016/j.ijscr.2017.09.016. Epub 2017 Sep 23.
Leiomyomatosis peritonealis disseminata (LPD) is a peculiar benign clinical disorder characterized by proliferation of peritoneal and subperitoneal nodules. LPD is a difficultly diagnosed benign disease that rarely degenerates into malignancy.
A 40-year-old Caucasian female with vaginal bleeding proceeded to our institution for elective excision of abdominal and pelvic masses which were firstly considered as leiomyosarcomas. The histologic diagnosis of the mass lesions revealed smooth muscle benign cells. This is the first case of LPD reported in Greece. A meticulous review of the literature was conducted as well.
The differential diagnosis of LPD is difficult due to its clinical resemblance with peritoneal carcinomatosis or metastatic lesions and with benign metastasizing leiomyoma (BML) as well. Etiological factors, pathophysiology and clinical manifestations which lead to a safe diagnosis of LPD are adequately described.
Surgeons' thorough knowledge concerning this rare clinical condition is fundamental and crucial in order to establish a correct diagnosis and assert the appropriate treatment and the minimization of the probability of malignant transformation of LPD.
播散性腹膜平滑肌瘤病（LPD）是一种特殊的良性临床病症，其特征为腹膜和腹膜下结节增生。LPD是一种难以诊断的良性疾病，很少恶变为恶性肿瘤。
一名40岁的白人女性因阴道出血前来我院择期切除腹部和盆腔肿块，这些肿块最初被认为是平滑肌肉瘤。肿块病变的组织学诊断显示为平滑肌良性细胞。这是希腊报道的首例LPD病例。同时还对文献进行了详尽回顾。
LPD的鉴别诊断较为困难，因为其在临床上与腹膜癌或转移性病变以及良性转移性平滑肌瘤（BML）相似。文中充分描述了导致LPD安全诊断的病因、病理生理学和临床表现。
外科医生对这种罕见临床病症的全面了解对于做出正确诊断、确定适当治疗方法以及将LPD恶性转化的可能性降至最低至关重要。
