两种新培育的肥胖同源近交系大鼠品系的激素水平比较

Comparative hormonal profile of two newly developed obese congenic rat strains.

Ellwood K C, Michaelis O E, Bhathena S J

U.S. Department of Agriculture, Beltsville Human Nutrition Research Center, MD 20705.

Comp Biochem Physiol A Comp Physiol. 1988;89(3):371-5. doi: 10.1016/0300-9629(88)91042-0.

Abstract

The effect of feeding diets containing either 54% sucrose or cooked corn starch for 12 weeks on levels of fasting plasma insulin, corticosterone, growth hormone and glucagon were compared in two newly developed genetically obese rat strains--the normoglycemic LA/N-cp and the diabetic SHR/N-cp. 2. In corpulent rats of either strain, levels of plasma insulin and corticosterone were greater when compared to the lean littermates. Corpulent LA/N-cp rats had lower levels of plasma glucagon and higher levels of plasma growth hormone than did lean LA/N-cp rats. 3. SHR/N-cp rats fed sucrose had greater levels of corticosterone and glucagon than did SHR/N-cp rats fed starch.

摘要

比较了两种新培育的遗传性肥胖大鼠品系——血糖正常的LA/N-cp和糖尿病性SHR/N-cp，喂食含54%蔗糖或熟玉米淀粉的日粮12周对空腹血浆胰岛素、皮质酮、生长激素和胰高血糖素水平的影响。2. 在任一品系的肥胖大鼠中，与瘦的同窝仔鼠相比，血浆胰岛素和皮质酮水平更高。肥胖的LA/N-cp大鼠比瘦的LA/N-cp大鼠血浆胰高血糖素水平更低，血浆生长激素水平更高。3. 喂食蔗糖的SHR/N-cp大鼠比喂食淀粉的SHR/N-cp大鼠皮质酮和胰高血糖素水平更高。