哮喘患者与对照组血清白细胞介素-33水平的比较及其与疾病严重程度的关系。
Comparison of Interleukin-33 Serum Levels in Asthmatic Patients with a Control Group and Relation with the Severity of the Disease.
作者信息
Momen Tooba, Ahanchian Hamid, Reisi Mohsen, Shamsdin Seyedeh Azra, Shahsanai Armindokht, Keivanfar Majid
机构信息
Division of Asthma, Allergy and Clinical Immunology, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Noncommunicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
FASA University of Medical Sciences, FASA, Iran.
出版信息
Int J Prev Med. 2017 Aug 31;8:65. doi: 10.4103/ijpvm.IJPVM_179_16. eCollection 2017.
BACKGROUND
The relation between interleukin-33 (IL-33) and asthma is not precisely known yet. The present study set to compare the serum level of IL-33 in patients with asthma and controls and study the relation with the severity of disease.
METHODS
The serum level of IL-33 and total IgE in 89 asthmatic patients and 57 controls were analyzed. The association of levels of IL-33 with the severity of disease, levels of total IgE, measures of spirometry (forced expiratory volume in 1 s [FEV1]), age, sex, presence or absence of other allergic diseases, and the disease duration was evaluated.
RESULTS
Higher levels of IL-33 and total IgE were detected in asthmatic patients compared with controls ( = 0.0001 and = 0.008, respectively). In the asthmatic group, a significant direct association of IL-33 with age ( = 0.02, = 0.23) and with total IgE level ( = 0.003, = 0.31) were observed, but there was no relationship between other variables. Comparison of mean level of IL-33 in different asthma groups concerning the disease severity showed the statistically significant difference between them and a significant increased serum level of total IgE was observed in more severe disease. The results showed a significant negative correlation between FEV1 and total IgE ( = 0.028, = -0.23) and IL-33 level ( = 0.0001, = -0.83).
CONCLUSIONS
IL-33 is suggested as a new inflammatory marker of severe and refractory asthma. Therefore, it may be a unique therapeutic target in these patients.
背景
白细胞介素-33（IL-33）与哮喘之间的关系尚未完全明确。本研究旨在比较哮喘患者与对照组的血清IL-33水平，并研究其与疾病严重程度的关系。
方法
分析了89例哮喘患者和57例对照组的血清IL-33和总IgE水平。评估了IL-33水平与疾病严重程度、总IgE水平、肺功能指标（第1秒用力呼气量[FEV1]）、年龄、性别、是否存在其他过敏性疾病以及病程之间的关联。
结果
与对照组相比，哮喘患者的IL-33和总IgE水平更高（分别为P = 0.0001和P = 0.008）。在哮喘组中，观察到IL-33与年龄（P = 0.02，r = 0.23）和总IgE水平（P = 0.003，r = 0.31）之间存在显著的正相关，但与其他变量之间没有关系。比较不同哮喘严重程度组的IL-33平均水平，发现它们之间存在统计学显著差异，且在病情更严重的患者中观察到总IgE血清水平显著升高。结果显示FEV1与总IgE（P = 0.028，r = -0.23）和IL-33水平（P = 0.0001，r = -0.83）之间存在显著负相关。
结论
IL-33被认为是重度和难治性哮喘的一种新的炎症标志物。因此，它可能是这些患者独特的治疗靶点。
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