Naksomboon Kananat, Valderas Carolina, Gómez-Martínez Melania, Álvarez-Casao Yolanda, Fernández-Ibáñez M Ángeles
Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands.
ACS Catal. 2017 Sep 1;7(9):6342-6346. doi: 10.1021/acscatal.7b02356. Epub 2017 Aug 18.
Pd(II)-catalyzed C-H functionalization of nondirected arenes has been realized using an inexpensive and easily accessible type of bidentate S,O-ligand. The catalytic system shows high efficiency in the C-H olefination reaction of electron-rich and electron-poor arenes. This methodology is operationally simple, scalable, and can be used in late-stage functionalization of complex molecules. The broad applicability of this catalyst has been showcased in other transformations such as Pd(II)-catalyzed C-H acetoxylation and allylation reactions.
使用一种廉价且易于获得的双齿S,O配体实现了钯(II)催化的非导向芳烃的C-H官能化。该催化体系在富电子和贫电子芳烃的C-H烯基化反应中显示出高效率。该方法操作简单、可扩展,可用于复杂分子的后期官能化。这种催化剂的广泛适用性已在其他转化反应中得到展示,如钯(II)催化的C-H乙酰氧基化和烯丙基化反应。