Guzick Andrew G, McNamara Joseph P H, Reid Adam M, Balkhi Amanda M, Storch Eric A, Murphy Tanya K, Goodman Wayne K, Bussing Regina, Geffken Gary R
University of Florida, College of Medicine, 8491 NW 39th Avenue, Gainesville, Florida, 32606.
University of Florida, College of Public Health and Health Professions, 1225 Center Drive, Gainesville, FL 32611, P.O. Box 100185.
J Obsessive Compuls Relat Disord. 2017 Jan;12:1-8. doi: 10.1016/j.jocrd.2016.11.004. Epub 2016 Nov 23.
Attention-deficit/hyperactivity disorder (ADHD) has been found to be highly comorbid in children and adolescents with obsessive-compulsive disorder (OCD). Some have proposed, however, that obsessive anxiety may cause inattention and executive dysfunction, leading to inappropriate ADHD diagnoses in those with OCD. If this were the case, these symptoms would be expected to decrease following successful OCD treatment. The present study tested this hypothesis and evaluated whether ADHD symptoms at baseline predicted OCD treatment response. Obsessive-compulsive and ADHD symptoms were assessed in 50 youth enrolled in a randomized controlled trial investigating selective serotonin reuptake inhibitor and cognitive behavioral treatment. Repeated-measures analysis of variance (RMANOVA) revealed that ADHD symptoms at baseline do not significantly predict treatment outcome. A multivariate RMANOVA found that OCD treatment response moderated change in inattention; participants who showed greater reduction in OCD severity experienced greater reduction in ADHD-inattentive symptoms, while those with less substantial reduction in obsessions and compulsions showed less change. These findings suggest that children and adolescents with OCD and inattention may experience meaningful improvements in attention problems following OCD treatment. Thus, in many youth with OCD, inattention may be inherently tied to obsessions and compulsions. Clinicians may consider addressing OCD in treatment before targeting inattentive-type ADHD.
注意缺陷多动障碍(ADHD)在患有强迫症(OCD)的儿童和青少年中被发现具有高度共病性。然而,一些人提出,强迫性焦虑可能导致注意力不集中和执行功能障碍,从而导致对患有OCD的人做出不恰当的ADHD诊断。如果是这样的话,预计在OCD成功治疗后这些症状会减轻。本研究检验了这一假设,并评估了基线时的ADHD症状是否能预测OCD治疗反应。对50名参加一项研究选择性5-羟色胺再摄取抑制剂和认知行为治疗的随机对照试验的青少年进行了强迫症状和ADHD症状评估。重复测量方差分析(RMANOVA)显示,基线时的ADHD症状不能显著预测治疗结果。多变量RMANOVA发现,OCD治疗反应调节了注意力不集中的变化;强迫症严重程度降低幅度更大的参与者,其ADHD注意力不集中症状的减轻幅度也更大,而强迫观念和强迫行为减少幅度较小的参与者,其变化也较小。这些发现表明,患有OCD和注意力不集中的儿童和青少年在OCD治疗后,注意力问题可能会有显著改善。因此,在许多患有OCD的青少年中,注意力不集中可能与强迫观念和强迫行为内在相关。临床医生在针对注意力不集中型ADHD进行治疗之前,可能会考虑先治疗OCD。