Cheng Karis Kin Fong, Ip Wan Yim, Lee Vincent, Li Chak Ho, Yuen Hui Leung, Epstein Joel B
Alice Lee Centre for Nursing Studies, National University of Singapore, Singapore.
School of Nursing, Hong Kong Sanatorium and Hospital, Hong Kong, China.
Asia Pac J Oncol Nurs. 2017 Oct-Dec;4(4):330-335. doi: 10.4103/apjon.apjon_39_17.
Oral mucositis is a frequent clinical condition that has been shown to affect pediatric cancer patients. Oral Mucositis Daily Questionnaire (OMDQ) is one of the few available patient-reported outcome measures to assess the extent and impact of oral mucositis. The objectives of the study were to translate the Mouth and Throat Soreness-Related Questions of the OMDQ into Chinese (OMDQ MTS-Ch) for children and adolescents aged 6-18 years receiving chemotherapy and to evaluate its psychometric properties.
This was part of a multicenter, prospective cohort study involving two phases. Phase I involved forward-backward translation to fit the cognitive and linguistic age level of the children and adolescents, followed by face and content validation, together with pretesting. In Phase II, which evaluated the internal consistency, test-retest reliability, and discriminant validity, a total of 140 patients completed the OMDQ MTS-Ch for 14 days.
The OMDQ MTS-Ch had satisfactory face and content validities. The Cronbach's alpha coefficient of the OMDQ MTS-Ch was 0.984. All of the corrected item-total correlations were higher than 0.90. The test-retest intraclass correlation coefficient between consecutive days for the OMDQ MTS-Ch items ranged from 0.576 to 0.983; the only value that was not over 0.70 was that for the paired study days 7 and 8 for the item of talking. The mean area-under-the-curve OMDQ MTS-Ch item scores were significantly different among patients with different degrees of mucositis severity ( < 0.001), supporting the discriminant validity.
It has been shown that the OMDQ MTS-Ch has a good level of reliability and discriminant validity and can be completed by children aged ≥6 years and adolescents on a daily basis to measure mucositis and its related functional limitations.
口腔黏膜炎是一种常见的临床病症,已证实会影响小儿癌症患者。口腔黏膜炎每日问卷(OMDQ)是少数可用于评估口腔黏膜炎程度和影响的患者报告结局指标之一。本研究的目的是将OMDQ中与口腔和咽喉疼痛相关的问题翻译成中文(OMDQ MTS-Ch),供6至18岁接受化疗的儿童和青少年使用,并评估其心理测量学特性。
这是一项多中心前瞻性队列研究的一部分,包括两个阶段。第一阶段涉及前后翻译以适应儿童和青少年的认知和语言年龄水平,随后进行表面效度和内容效度验证以及预测试。在评估内部一致性、重测信度和区分效度的第二阶段,共有140名患者连续14天完成了OMDQ MTS-Ch。
OMDQ MTS-Ch具有令人满意的表面效度和内容效度。OMDQ MTS-Ch的Cronbach's α系数为0.984。所有校正后的项目与总分相关性均高于0.90。OMDQ MTS-Ch项目连续几天的重测组内相关系数在0.576至0.983之间;唯一未超过0.70的值是谈话项目配对研究日7和8的相关系数。不同程度口腔黏膜炎严重程度的患者之间,OMDQ MTS-Ch项目得分的平均曲线下面积存在显著差异(<0.001),支持区分效度。
已表明OMDQ MTS-Ch具有良好的信度和区分效度,6岁及以上儿童和青少年可以每天完成该问卷,以测量口腔黏膜炎及其相关功能限制。