Division of Haematology/Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada.
Support Care Cancer. 2012 Jun;20(6):1251-8. doi: 10.1007/s00520-011-1211-z. Epub 2011 Jun 17.
The objectives of this study were to examine the psychometric properties of the self-report Oral Mucositis Daily Questionnaire (OMDQ) and to measure the importance of mucositis in children receiving intensive chemotherapy.
Children ≥ 12 years of age receiving intensive chemotherapy for leukemia/lymphoma or undergoing stem cell transplantation were asked to complete the OMDQ daily for 21 days after chemotherapy. Other measures of mucositis obtained concurrently with OMDQ included the World Health Organization (WHO) mucositis scale, the pain visual analog scale (VAS), and the Functional Assessment of Cancer Therapy Esophageal Cancer Sub-scale (FACT-ECS). The importance of mucositis was estimated using a VAS, time trade-off technique, and willingness to pay to avoid mucositis.
Fifteen children participated. Test-retest reliability demonstrated at least moderate correlation for all questions within the OMDQ. Assessment of construct validity of the OMDQ revealed at least moderate correlation with WHO, VAS, and FACT-ECS for questions regarding pain, swallowing, drinking, and eating. Effect on sleeping and talking had lower correlations than that expected a priori. The diarrhea question of the OMDQ did not correlate with other measures of mucositis. Severe mucositis is important to children, while mild mucositis is less important to them. Children were willing to pay moderate amounts of money to prevent mucositis.
The OMDQ exhibits test-retest reliability, and most questions show construct validity with the exceptions of the sleep, talking, and diarrhea questions. Therefore, the OMDQ should not be used unmodified as a self-report instrument in children with cancer. Severe mucositis is of importance to these children.
本研究的目的是检验自我报告的口腔粘膜炎每日问卷（OMDQ）的心理测量特性，并测量接受强化化疗的儿童中粘膜炎的重要性。
≥ 12 岁的正在接受白血病/淋巴瘤强化化疗或进行干细胞移植的儿童，在化疗后 21 天内每天填写 OMDQ。同时获得的其他粘膜炎测量方法包括世界卫生组织（WHO）粘膜炎量表、疼痛视觉模拟量表（VAS）和癌症治疗功能评估-食管癌子量表（FACT-ECS）。使用 VAS、时间权衡技术和避免粘膜炎的意愿支付来估计粘膜炎的重要性。
15 名儿童参与了研究。OMDQ 中的所有问题的重测信度至少为中度相关。对 OMDQ 的结构有效性评估显示，与 WHO、VAS 和 FACT-ECS 相比，关于疼痛、吞咽、饮水和进食的问题至少具有中度相关性。对睡眠和说话的影响的相关性低于预期。OMDQ 的腹泻问题与其他粘膜炎测量方法不相关。严重的粘膜炎对儿童很重要，而轻度的粘膜炎对他们则不太重要。儿童愿意支付适量的钱来预防粘膜炎。
OMDQ 具有重测信度，大多数问题与除睡眠、说话和腹泻问题之外的其他问题具有结构有效性。因此，OMDQ 不应在癌症儿童中未经修改作为自我报告工具使用。严重的粘膜炎对这些儿童很重要。
