Ojha S, Deep S, Kundu S
School of Biochemical Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi - 221005, India.
Cell Mol Biol (Noisy-le-grand). 2017 Jul 31;63(6):52-55. doi: 10.14715/cmb/2017.63.6.11.
Due to an increase in the occurrence of multi drug resistant microorganisms a need for the development of alternative drugs comes in light. This alternative drug should be such that the microorganisms should not be able to develop resistance against them easily. Antimicrobial peptides are the most potential candidates to be developed as alternative drug. In the present study the three toxins ETA, ETB and PVL of Staphylococcus aureus were docked with four antimicrobial peptides, Ib-AMP1, JCPep7, Snakin2, Sesquin, derived from plants. The docking studies predict that Ib-AMP1 shows significant interactions with all these three toxins. Hence, further studies can be carried out for developing Ib-AMP1 as an alternative drug against the toxins of Staphylococcus aureus.
由于多重耐药微生物的出现频率增加，开发替代药物的需求应运而生。这种替代药物应使微生物难以轻易对其产生耐药性。抗菌肽是最有潜力开发为替代药物的候选物。在本研究中，金黄色葡萄球菌的三种毒素ETA、ETB和PVL与四种源自植物的抗菌肽Ib-AMP1、JCPep7、Snakin2、Sesquin进行了对接。对接研究预测，Ib-AMP1与所有这三种毒素都有显著相互作用。因此，可以进一步开展研究，将Ib-AMP1开发为对抗金黄色葡萄球菌毒素的替代药物。
