Parekh R B, Roitt I M, Isenberg D A, Dwek R A, Ansell B M, Rademacher T W
Department of Biochemistry, University of Oxford.
Lancet. 1988 Apr 30;1(8592):966-9. doi: 10.1016/s0140-6736(88)91781-3.
The prevalence of agalactosyl N-linked oligosaccharides on serum IgG was determined for patients with juvenile onset and with adult rheumatoid arthritis. A significant difference in the prevalence of these structures from age matched controls was found in both types of arthritis. In patients with adult onset rheumatoid arthritis, the results showed a strong correlation between the prevalence of IgG-associated agalactosyl oligosaccharides and disease activity. A correlation between disease activity and agalactosyl structures was also seen in a retrospective analysis of serial IgG samples from patients with juvenile onset disease. The finding that childhood onset arthritis and adult rheumatoid arthritis share a defect of glycosylation of serum IgG suggests that there may be a greater similarity between these two varieties of rheumatoid arthritis than has been hitherto considered. The observation that the incidence of agalactosyl oligosaccharides on IgG fluctuates with disease activity provides indirect evidence for a seminal role for this change of glycosylation in the inflammatory process which, in rheumatoid arthritis, is focused on the synovial tissues and results in bone erosions and joint destruction.
测定了青少年型和成人型类风湿性关节炎患者血清IgG上无半乳糖基N-连接寡糖的患病率。在这两种类型的关节炎中，均发现这些结构的患病率与年龄匹配的对照组存在显著差异。在成人型类风湿性关节炎患者中，结果显示与IgG相关的无半乳糖基寡糖的患病率与疾病活动度之间存在很强的相关性。在对青少年型疾病患者的系列IgG样本进行的回顾性分析中，也发现了疾病活动度与无半乳糖基结构之间的相关性。儿童期发病的关节炎和成人型类风湿性关节炎在血清IgG糖基化方面存在缺陷这一发现表明，这两种类风湿性关节炎之间的相似性可能比迄今所认为的更大。IgG上无半乳糖基寡糖的发生率随疾病活动度波动这一观察结果，为这种糖基化变化在炎症过程中的关键作用提供了间接证据，在类风湿性关节炎中，炎症过程集中在滑膜组织，导致骨侵蚀和关节破坏。
