类风湿关节炎（RA）、青少年慢性关节炎（JCA）和干燥综合征（SS）中IgG上暴露的半乳糖与N-乙酰葡糖胺残基之间的关系。
The relationship between exposed galactose and N-acetylglucosamine residues on IgG in rheumatoid arthritis (RA), juvenile chronic arthritis (JCA) and Sjögren's syndrome (SS).
作者信息
Bond A, Alavi A, Axford J S, Youinou P, Hay F C
机构信息
Department of Cellular and Molecular Sciences, St George's Hospital Medical School, London, UK.
出版信息
Clin Exp Immunol. 1996 Jul;105(1):99-103. doi: 10.1046/j.1365-2249.1996.d01-741.x.
The relationship between exposed galactose and N-acetylglucosamine on IgG in RA, JCA and SS was investigated. This was achieved using IgG isolated from serum where the levels of galactose and N-acetylglucosamine (GlcNAc) were detected using biotinylated lectins. Galactose and GlcNAc on IgG from patients with RA and JCA are inversely related, but in contrast, in SS, galactose expression on IgG decreased while GlcNAc expression remained similar to normal levels. Alterations in IgG glycosylation are closely associated with the development of adult and juvenile chronic arthritis and SS, but the changes involved are different in RA compared with SS, suggesting that the precise pattern of exposed sugars is associated with different rheumatological diseases.
研究了类风湿关节炎（RA）、幼年特发性关节炎（JCA）和干燥综合征（SS）中IgG上暴露的半乳糖与N-乙酰葡糖胺之间的关系。这是通过从血清中分离IgG来实现的，其中半乳糖和N-乙酰葡糖胺（GlcNAc）的水平使用生物素化凝集素进行检测。RA和JCA患者IgG上的半乳糖和GlcNAc呈负相关，但相比之下，在SS中，IgG上的半乳糖表达下降，而GlcNAc表达仍与正常水平相似。IgG糖基化的改变与成人和青少年慢性关节炎以及SS的发展密切相关，但RA与SS相比所涉及的变化不同，这表明暴露糖的精确模式与不同的风湿性疾病相关。
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