Zhang Junwu, Guo Zhen, Yang Wei, Zhu Zhongliang, Kong Wanzhong, Zheng Sujie, Jiang Lei, Fei Xianming, Chen Yanxia, Liu Jinlin
Department of Clinical Laboratory, Wenzhou Traditional Chinese Medicine Hospital, 325000 Wenzhou, China.
Department of Clinical Laboratory, Second Affiliated Hospital, School of Medicine, Zhejiang University, 310009 Hangzhou, China.
Oncotarget. 2017 Jul 12;8(38):63971-63977. doi: 10.18632/oncotarget.19250. eCollection 2017 Sep 8.
Various indices have been used to assess Crohn's disease (CD). However, the question of whether the Crohn's Disease Activity Index (CDAI) is associated with coagulation function has not been fully confirmed. In this study, we examined the association between CDAI and the coagulation and fibrinolysis parameters. In a retrospective and observational cohort study, the CDAI of 108 patients from two hospital centers was calculated, and its correlations with the prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), international normalization ratio (INR), fibrinogen (Fg) and plasma D-Dimer were investigated. Significant differences were found for PT, APTT, TT, INR, Fg and D-Dimer between the healthy controls and CD patients. However, no significant difference was found between the CDAI-High and CDAI-Low groups of CD patients. Moreover, the CDAI was positively correlated with the level of D-Dimer in CD patients of two hospitals, regardless of the detection method (hospital 1: r=0.3268, = 0.0042; hospital 2: r=0.5553, =0.0008). Among the blood coagulation and fibrinolysis parameters, the D-Dimer level was highly correlated with CDAI in CD patients. Thus, the level of D-Dimer expression may be a promising new marker for assessing CD disease activity.
多种指标已被用于评估克罗恩病（CD）。然而，克罗恩病活动指数（CDAI）是否与凝血功能相关的问题尚未得到充分证实。在本研究中，我们检测了CDAI与凝血和纤溶参数之间的关联。在一项回顾性观察队列研究中，计算了来自两个医院中心的108例患者的CDAI，并研究了其与凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、国际标准化比值（INR）、纤维蛋白原（Fg）和血浆D - 二聚体的相关性。健康对照组与CD患者之间的PT、APTT、TT、INR、Fg和D - 二聚体存在显著差异。然而，CD患者的CDAI - 高分组与CDAI - 低分组之间未发现显著差异。此外，无论检测方法如何（医院1：r = 0.3268，P = 0.0042；医院2：r = 0.5553，P = 0.0008），两所医院的CD患者中CDAI均与D - 二聚体水平呈正相关。在凝血和纤溶参数中，CD患者的D - 二聚体水平与CDAI高度相关。因此，D - 二聚体表达水平可能是评估CD疾病活动度的一个有前景的新标志物。
