Division of Preparatory Programs for Overseas Chinese Students, National Taiwan Normal University , Linkou, 24449, Taiwan.
J Org Chem. 2017 Oct 20;82(20):11084-11090. doi: 10.1021/acs.joc.7b02035. Epub 2017 Oct 9.
A three-component cascade cyclization was developed to synthesize 2,3-diarylisoindolin-1-one by using 2-formylbenzonitrile, arenes, and diaryliodonium salts. The process underwent copper-catalyzed tandem C-N/C-C bond formation, producing isoindolin-1-one derivatives in good to excellent yields.
发展了一种三组分级联环化反应，通过使用 2-甲酰基苯甲腈、芳基和二芳基碘鎓盐合成 2,3-二芳基异吲哚啉-1-酮。该过程经历了铜催化的串联 C-N/C-C 键形成，以良好至优异的收率得到了异吲哚啉-1-酮衍生物。
