2-甲酰苯腈、芳基和二芳基碘鎓盐的铜催化级联环化反应合成 2,3-二芳基异吲哚啉-1-酮
Synthesis of 2,3-Diarylisoindolin-1-one by Copper-Catalyzed Cascade Annulation of 2-Formylbenzonitriles, Arenes, and Diaryliodonium Salts.
机构信息
Division of Preparatory Programs for Overseas Chinese Students, National Taiwan Normal University , Linkou, 24449, Taiwan.
出版信息
J Org Chem. 2017 Oct 20;82(20):11084-11090. doi: 10.1021/acs.joc.7b02035. Epub 2017 Oct 9.
PMID:28969415
Abstract
A three-component cascade cyclization was developed to synthesize 2,3-diarylisoindolin-1-one by using 2-formylbenzonitrile, arenes, and diaryliodonium salts. The process underwent copper-catalyzed tandem C-N/C-C bond formation, producing isoindolin-1-one derivatives in good to excellent yields.
摘要
发展了一种三组分级联环化反应，通过使用 2-甲酰基苯甲腈、芳基和二芳基碘鎓盐合成 2,3-二芳基异吲哚啉-1-酮。该过程经历了铜催化的串联 C-N/C-C 键形成，以良好至优异的收率得到了异吲哚啉-1-酮衍生物。
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