University of Miami, Department of Dermatology and Cutaneous Surgery, Miami Itch Center, 1600 NW 10th Ave RMSB2063, Miami, FL 33136, USA.
University of Miami, Department of Dermatology and Cutaneous Surgery, Miami Itch Center, 1600 NW 10th Ave RMSB2063, Miami, FL 33136, USA.
Neurosci Biobehav Rev. 2018 Apr;87:17-26. doi: 10.1016/j.neubiorev.2018.01.009. Epub 2018 Jan 31.
Chronic itch is associated with increased stress, anxiety, and other mood disorders. In turn, stress and anxiety exacerbate itch, leading to a vicious cycle that affects patient behavior (scratching) and worsens disease prognosis and quality of life. This cycle persists across chronic itch conditions of different etiologies and even to some extent in healthy individuals, suggesting that the final common pathway for itch processing (the central nervous system) plays a major role in the relationship between itch and anxiety. Pharmacological and nonpharmacological treatments that reduce anxiety have shown promising anti-itch effects. Further research is needed to establish specific central mechanisms of the itch-anxiety cycle and provide new targets for treatment.
慢性瘙痒与压力、焦虑和其他情绪障碍有关。反过来，压力和焦虑又会加重瘙痒，导致一个恶性循环，影响患者的行为（搔抓），并使疾病预后和生活质量恶化。这种循环存在于不同病因的慢性瘙痒症中，甚至在一定程度上存在于健康个体中，这表明瘙痒处理的最终共同途径（中枢神经系统）在瘙痒和焦虑之间的关系中起着重要作用。减少焦虑的药物和非药物治疗已显示出有希望的抗瘙痒作用。需要进一步研究以确定瘙痒-焦虑循环的特定中枢机制，并为治疗提供新的靶点。
