CMTR1 依赖性 mRNA 帽甲基化的调控与功能
Regulation and function of CMTR1-dependent mRNA cap methylation.
作者信息
Inesta-Vaquera Francisco, Cowling Victoria H
机构信息
Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee, UK.
出版信息
Wiley Interdiscip Rev RNA. 2017 Nov;8(6). doi: 10.1002/wrna.1450. Epub 2017 Oct 2.
Abstract
mRNA is modified co-transcriptionally at the 5' end by the addition of an inverted guanosine cap structure which can be methylated at several positions. The mRNA cap recruits proteins involved in gene expression and identifies the transcript as being cellular or 'self' in the innate immune response. Methylation of the first transcribed nucleotide on the ribose 2'-O position is a prevalent cap modification which has roles in splicing, translation and provides protection against the innate immune response. In this review, we discuss the regulation and function of CMTR1, the first transcribed nucleotide ribose 2'-O methyltransferase, and the molecular interactions which mediate methylated 2'-O ribose function. WIREs RNA 2017, 8:e1450. doi: 10.1002/wrna.1450 For further resources related to this article, please visit the WIREs website.
摘要
信使核糖核酸（mRNA）在转录过程中通过添加一个反向鸟苷帽结构在5'端进行修饰，该结构可在多个位置甲基化。mRNA帽招募参与基因表达的蛋白质，并在先天免疫反应中将转录本识别为细胞的或“自身”的。核糖2'-O位置上第一个转录核苷酸的甲基化是一种普遍的帽修饰，它在剪接、翻译中起作用，并提供针对先天免疫反应的保护。在这篇综述中，我们讨论了首个转录核苷酸核糖2'-O甲基转移酶CMTR1的调控和功能，以及介导甲基化2'-O核糖功能的分子相互作用。《WIREs RNA》2017年，8卷：e1450。doi: 10.1002/wrna.1450 有关本文的更多资源，请访问WIREs网站。
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