Rethinking mA Readers, Writers, and Erasers.

In recent years, mA has emerged as an abundant and dynamically regulated modification throughout the transcriptome. Recent technological advances have enabled the transcriptome-wide identification of mA residues, which in turn has provided important insights into the biology and regulation of this pervasive regulatory mark. Also central to our current understanding of mA are the discovery and characterization of mA readers, writers, and erasers. Over the last few years, studies into the function of these proteins have led to important discoveries about the regulation and function of mA. However, during this time our understanding of these proteins has also evolved considerably, sometimes leading to the reversal of early concepts regarding the reading, writing and erasing of mA. In this review, we summarize recent advances in mA research, and we highlight how these new findings have reshaped our understanding of how mA is regulated in the transcriptome.