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2
Hyperuricemia and risk of increased arterial stiffness in healthy women based on health screening in Korean population.基于韩国人群健康筛查的健康女性高尿酸血症与动脉僵硬度增加风险
PLoS One. 2017 Jun 30;12(6):e0180406. doi: 10.1371/journal.pone.0180406. eCollection 2017.
3
Sex differences in gout characteristics: tailoring care for women and men.痛风特征的性别差异：针对女性和男性的个性化护理
BMC Musculoskelet Disord. 2017 Mar 14;18(1):108. doi: 10.1186/s12891-017-1465-9.
4
Global epidemiology of gout: prevalence, incidence and risk factors.痛风的全球流行病学：患病率、发病率和危险因素。
Nat Rev Rheumatol. 2015 Nov;11(11):649-62. doi: 10.1038/nrrheum.2015.91. Epub 2015 Jul 7.
5
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6
Racial and gender disparities among patients with gout.痛风患者中的种族和性别差异。
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Impact of obesity and hypertriglyceridemia on gout development with or without hyperuricemia: a prospective study.肥胖和高三酰甘油血症对有或无高尿酸血症的痛风发病的影响：一项前瞻性研究。
Arthritis Care Res (Hoboken). 2013 Jan;65(1):133-40. doi: 10.1002/acr.21824.
8
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9
Trends in hyperuricemia and gout prevalence: Nutrition and Health Survey in Taiwan from 1993-1996 to 2005-2008.高尿酸血症和痛风患病率的趋势：1993 - 1996年至2005 - 2008年台湾营养与健康调查
Asia Pac J Clin Nutr. 2011;20(2):301-8.
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Risk factors for gout and prevention: a systematic review of the literature.痛风的危险因素及预防：文献系统综述。
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成年台湾人群中，HLA-B 多态性变异对性别和高血脂与痛风风险之间相互作用的影响

The Interaction between Sex and Hyperlipidemia on Gout Risk Is Modulated by HLA-B Polymorphic Variants in Adult Taiwanese.

机构信息

Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.

Superintendent Office, Cathay General Hospital, Taipei 106, Taiwan.

出版信息

Genes (Basel). 2019 Mar 25;10(3):246. doi: 10.3390/genes10030246.

DOI:10.3390/genes10030246
PMID:30934611
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6470813/
Abstract

The effects of genetic variants on the interaction between hyperlipidemia and sex have not been investigated among gout patients in Taiwan. Using Taiwan Biobank and the National Health Insurance Research Database (NHIRD), we examined hyperlipidemia, sex, and their relationship with gout among Taiwanese adults with the human leukocyte antigen B (HLA-B) genetic variants. Hyperlipidemia was present in 1437 patients with gout. Sex and hyperlipidemia had significant associations on gout risk, with hyperlipidemia showing a relatively stronger effect. Gout was present in men, with an odds ratio (OR) of 1.945 (95% confidence interval (CI) 1.568⁻2.411) compared to women, and in hyperlipidemic (OR = 4.032; 95% CI: 3.581⁻4.540) compared to non-hyperlipidemic patients. The interaction of sex and hyperlipidemia was significant for rs2523608 GG ( = 0.0402) and rs4713518 AA ( = 0.0003) genotypes. After stratification, hyperlipidemia remained a risk factor in women (OR = 4.735, 95% CI: 3.375⁻6.643) and men (OR = 3.640, 95% CI: 2.916⁻4.544) with rs2523608 GG genotype. The odds ratio in hyperlipidemic women and men with rs4713518 AA genotype was 7.454 (95% CI 5.103⁻10.888) and 3.585 (95% CI 2.854⁻4.503), respectively. Our study indicates that hyperlipidemia-sex interactions exist for gout risk in Taiwanese adults with rs2523608 GG and rs4713518 AA genotypes.

摘要

在台湾的痛风患者中，尚未研究遗传变异对高血脂与性别相互作用的影响。本研究利用台湾生物银行和全民健康保险研究数据库（NHIRD），在携带人类白细胞抗原 B（HLA-B）遗传变异的台湾成年人中，检测了高血脂、性别及其与痛风之间的关系。在 1437 例痛风患者中存在高血脂。性别和高血脂与痛风风险显著相关，高血脂的影响相对更强。与女性相比，男性痛风的比值比（OR）为 1.945（95%置信区间（CI）1.568⁻2.411），与非高血脂患者相比，高血脂患者痛风的 OR 为 4.032（95% CI：3.581⁻4.540）。性别和高血脂的交互作用在 rs2523608 GG（ = 0.0402）和 rs4713518 AA（ = 0.0003）基因型中具有统计学意义。分层后，高血脂仍是 rs2523608 GG 基因型女性（OR = 4.735，95% CI：3.375⁻6.643）和男性（OR = 3.640，95% CI：2.916⁻4.544）痛风的危险因素。rs4713518 AA 基因型高血脂女性和男性的 OR 分别为 7.454（95% CI 5.103⁻10.888）和 3.585（95% CI 2.854⁻4.503）。本研究表明，在携带 rs2523608 GG 和 rs4713518 AA 基因型的台湾成年痛风患者中，高血脂与性别存在交互作用。