Ghajavand Hasan, Esfahani Bahram Nasr, Havaei Asghar, Fazeli Hossein, Jafari Reyhaneh, Moghim Sharareh
Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Department of Microbiology, School of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, I.R. Iran.
Res Pharm Sci. 2017 Oct;12(5):373-380. doi: 10.4103/1735-5362.213982.
Increasing multiple drug resistant (MDR) strains of has aggravated curiosity in development of alternative therapy. Bacteriophages are often considered as alternative agents for controlling infections. In the present study two lytic phages for MDR were isolated and their efficacy and host ranges were evaluated. The phages were isolated from hospital wastewater. Electron microscopy revealed that IsfAB78 might belong to and IsfAB39 to . Initial characterization of phages showed that they have narrow host range and failed to infect relative and non-relative bacteria. Both phages decreased the turbidity significantly, indicating that these isolated phages may be considered as candidates for phage therapy.
多重耐药（MDR）菌株的不断增加加剧了人们对替代疗法开发的好奇心。噬菌体常被视为控制感染的替代剂。在本研究中，分离出了两种针对MDR的裂解性噬菌体，并评估了它们的功效和宿主范围。这些噬菌体是从医院废水中分离出来的。电子显微镜显示，IsfAB78可能属于[噬菌体所属类别1]，IsfAB39属于[噬菌体所属类别2]。噬菌体的初步特性表明它们的宿主范围狭窄，无法感染相关和非相关细菌。两种噬菌体均显著降低了[细菌名称]的浊度，表明这些分离出的噬菌体可被视为噬菌体疗法的候选者。
