Dragsted Lars O, Gao Qian, Praticò Giulia, Manach Claudine, Wishart David S, Scalbert Augustin, Feskens Edith J M
Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Department of Food Science, University of Copenhagen, Copenhagen, Denmark.
Genes Nutr. 2017 Sep 29;12:24. doi: 10.1186/s12263-017-0578-y. eCollection 2017.
In the dietary and health research area, biomarkers are extensively used for multiple purposes. These include biomarkers of dietary intake and nutrient status, biomarkers used to measure the biological effects of specific dietary components, and biomarkers to assess the effects of diet on health. The implementation of biomarkers in nutritional research will be important to improve measurements of dietary intake, exposure to specific dietary components, and of compliance to dietary interventions. Biomarkers could also help with improved characterization of nutritional status in study volunteers and to provide much mechanistic insight into the effects of food components and diets. Although hundreds of papers in nutrition are published annually, there is no current ontology for the area, no generally accepted classification terminology for biomarkers in nutrition and health, no systematic validation scheme for these biomarker classes, and no recent systematic review of all proposed biomarkers for food intake. While advanced databases exist for the human and food metabolomes, additional tools are needed to curate and evaluate current data on dietary and health biomarkers. The Food Biomarkers Alliance (FoodBAll) under the Joint Programming Initiative-A Healthy Diet for a Healthy Life (JPI-HDHL)-is aimed at meeting some of these challenges, identifying new dietary biomarkers, and producing new databases and review papers on biomarkers for nutritional research. This current paper outlines the needs and serves as an introduction to this thematic issue of on dietary and health biomarkers.
在饮食与健康研究领域，生物标志物被广泛用于多种目的。这些目的包括饮食摄入和营养状况的生物标志物、用于测量特定饮食成分生物学效应的生物标志物，以及评估饮食对健康影响的生物标志物。在营养研究中应用生物标志物对于改进饮食摄入量、特定饮食成分暴露量以及饮食干预依从性的测量将具有重要意义。生物标志物还有助于更好地描述研究志愿者的营养状况，并深入了解食物成分和饮食的作用机制。尽管每年有数百篇营养学论文发表，但该领域目前没有本体论，没有营养与健康领域生物标志物普遍接受的分类术语，没有针对这些生物标志物类别的系统验证方案，也没有对所有提议的食物摄入量生物标志物进行近期的系统综述。虽然存在人类和食物代谢组的先进数据库，但仍需要额外的工具来整理和评估当前关于饮食与健康生物标志物的数据。联合规划倡议——健康生活的健康饮食（JPI - HDHL）下的食物生物标志物联盟（FoodBAll）旨在应对其中一些挑战，识别新的饮食生物标志物，并生成关于营养研究生物标志物的新数据库和综述论文。本文概述了相关需求，并作为本期关于饮食与健康生物标志物专题的引言。
