Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL 33617, USA.
Cancer Control and Population Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.
Nutrients. 2022 Apr 2;14(7):1496. doi: 10.3390/nu14071496.
Cancer-related fatigue (CRF) is considered one of the most frequent and distressing symptoms for cancer survivors. Despite its high prevalence, factors that predispose, precipitate, and perpetuate CRF are poorly understood. Emerging research focuses on cancer and treatment-related nutritional complications, changes in body composition, and nutritional deficiencies that can compound CRF. Nutritional metabolomics, the novel study of diet-related metabolites in cells, tissues, and biofluids, offers a promising tool to further address these research gaps. In this position paper, we examine CRF risk factors, summarize metabolomics studies of CRF, outline dietary recommendations for the prevention and management of CRF in cancer survivorship, and identify knowledge gaps and challenges in applying nutritional metabolomics to understand dietary contributions to CRF over the cancer survivorship trajectory.
癌症相关疲劳（CRF）被认为是癌症幸存者中最常见和最令人痛苦的症状之一。尽管其发病率很高，但导致 CRF 的易患因素、诱发因素和持续因素仍了解甚少。新兴的研究重点关注癌症和治疗相关的营养并发症、身体成分的变化以及可能加重 CRF 的营养缺乏。营养代谢组学是对细胞、组织和生物流体中与饮食相关的代谢物的新研究，为进一步解决这些研究空白提供了有希望的工具。在这份立场文件中，我们检查了 CRF 的风险因素，总结了 CRF 的代谢组学研究，概述了癌症幸存者中预防和管理 CRF 的饮食建议，并确定了在应用营养代谢组学来了解饮食对癌症幸存者轨迹中 CRF 的贡献方面的知识差距和挑战。
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