Gao Qian, Praticò Giulia, Scalbert Augustin, Vergères Guy, Kolehmainen Marjukka, Manach Claudine, Brennan Lorraine, Afman Lydia A, Wishart David S, Andres-Lacueva Cristina, Garcia-Aloy Mar, Verhagen Hans, Feskens Edith J M, Dragsted Lars O
Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Department of Food Science, University of Copenhagen, Copenhagen, Denmark.
Genes Nutr. 2017 Dec 12;12:34. doi: 10.1186/s12263-017-0587-x. eCollection 2017.
Biomarkers are an efficient means to examine intakes or exposures and their biological effects and to assess system susceptibility. Aided by novel profiling technologies, the biomarker research field is undergoing rapid development and new putative biomarkers are continuously emerging in the scientific literature. However, the existing concepts for classification of biomarkers in the dietary and health area may be ambiguous, leading to uncertainty about their application. In order to better understand the potential of biomarkers and to communicate their use and application, it is imperative to have a solid scheme for biomarker classification that will provide a well-defined ontology for the field. In this manuscript, we provide an improved scheme for biomarker classification based on their intended use rather than the technology or outcomes (six subclasses are suggested: food compound intake biomarkers (FCIBs), food or food component intake biomarkers (FIBs), dietary pattern biomarkers (DPBs), food compound status biomarkers (FCSBs), effect biomarkers, physiological or health state biomarkers). The application of this scheme is described in detail for the dietary and health area and is compared with previous biomarker classification for this field of research.
生物标志物是检测摄入量或暴露量及其生物学效应以及评估系统易感性的有效手段。在新型分析技术的辅助下，生物标志物研究领域正在迅速发展，科学文献中不断涌现出新的假定生物标志物。然而，饮食与健康领域中生物标志物的现有分类概念可能不够明确，导致其应用存在不确定性。为了更好地理解生物标志物的潜力并交流其用途和应用，必须有一个可靠的生物标志物分类方案，为该领域提供明确的本体论。在本手稿中，我们基于生物标志物的预期用途而非技术或结果，提供了一种改进的分类方案（建议分为六个子类：食物化合物摄入生物标志物（FCIBs）、食物或食物成分摄入生物标志物（FIBs）、饮食模式生物标志物（DPBs）、食物化合物状态生物标志物（FCSBs）、效应生物标志物、生理或健康状态生物标志物）。详细描述了该方案在饮食与健康领域的应用，并与该研究领域以前的生物标志物分类进行了比较。
