Azuma Y, Shinohara M, Ito N, Mori M
J Periodontol. 1979 Aug;50(8):416-8. doi: 10.1902/jop.1979.50.8.416.
The toxicity tests of the dental plaque from ODU plaque-susceptible rats showed strong lethal effect on mice, and abscess forming effect on guinea-pigs. Bacterial cells isolated from the rat dental plaque also showed strong toxicity on both animals and capillary permeable activity on rabbits. Among these bacterial cells, Corynebacterium showed the strongest toxic effects on these animals. These facts suggested an important role of the dental plaque on initiation and development of gingivitis and that especially Corynebacterium may play an important role on gingivitis in ODU plaque-susceptible rats.
对ODU菌斑易感大鼠的牙菌斑进行的毒性测试表明，其对小鼠有强烈的致死作用，对豚鼠有脓肿形成作用。从大鼠牙菌斑中分离出的细菌细胞对这两种动物也表现出强烈的毒性，对兔子有毛细血管通透活性。在这些细菌细胞中，棒状杆菌对这些动物表现出最强的毒性作用。这些事实表明牙菌斑在牙龈炎的发生和发展中起重要作用，特别是棒状杆菌可能在ODU菌斑易感大鼠的牙龈炎中起重要作用。
