Ohura K, Ito N, Mori M
J Periodontol. 1981 Dec;52(12):758-60. doi: 10.1902/jop.1981.52.12.758.
The purpose of this study was to document the histological development of gingivitis in the plaque-susceptible ODU rat. Specimens were taken every 3 months over a 12 month period. In the 1st month a mile lymphocytic infiltrate was seen near the junctional epithelium. This infiltrate spread to the deeper connective tissue by the 3rd month. In the 6 to 9 month animals the cells of the junctional epithelium were partially destroyed resulting in beginning of sulcus ulceration. At this time osteoclasts were noted. By 12 months the cellular infiltrate was diffuse and large macrophages were evident. There were numerous enlarged capillaries.
本研究的目的是记录菌斑易感的ODU大鼠牙龈炎的组织学发展过程。在12个月的时间里，每3个月采集一次样本。在第1个月时，在结合上皮附近可见轻度淋巴细胞浸润。到第3个月时，这种浸润扩散到更深的结缔组织。在6至9个月大的动物中，结合上皮细胞部分被破坏，导致龈沟开始溃疡。此时可见破骨细胞。到12个月时，细胞浸润弥漫，可见大量巨噬细胞。有许多扩张的毛细血管。
