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潜在的濒死期供肾的产量。

Potential yield of imminent death kidney donation.

机构信息

Department of Medicine, University of Wisconsin, Madison, WI, USA.

Departments of Pediatrics and Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.

出版信息

Am J Transplant. 2018 Feb;18(2):486-491. doi: 10.1111/ajt.14524. Epub 2017 Nov 11.

DOI:10.1111/ajt.14524
PMID:28975705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5937230/
Abstract

About 99 000 people are waiting for a kidney in the United States, and many will die waiting. The concept of "imminent death" donation, a type of living donation, has been gaining attention among physicians, patients, and ethicists. We estimated the number of potential imminent death kidney donors at the University of Wisconsin Hospital and Clinics by assessing the number of annual deaths in individuals with normal kidney function. Based on a previous survey suggesting that one-third of patients might be willing to donate at imminent death, we estimate that between 76 and 396 people in the state of Wisconsin would be medically eligible and willing to donate each year at the time of imminent death. We extrapolated these numbers to all transplant centers in the United States, estimating that between 5925 and 31 097 people might be eligible and willing to donate each year. Our results suggest that allowing donation at imminent death and including discussions about organ donation in end-of-life planning could substantially reduce the nation's kidney waiting list while providing many more donors the opportunity to give this gift.

摘要

在美国,大约有 99000 人在等待肾脏,其中许多人将在等待中死亡。“即将死亡”捐赠的概念,即一种活体捐赠,已经引起了医生、患者和伦理学家的关注。我们通过评估肾功能正常的个体的年死亡人数,估计了威斯康星大学医院和诊所的潜在“即将死亡”的肾脏捐赠者数量。根据一项此前的调查显示,可能有三分之一的患者愿意在即将死亡时捐献器官,我们估计每年在即将死亡时,威斯康星州有 76 到 396 人在医学上有资格并愿意捐献。我们将这些数字推断到全美所有的移植中心,估计每年可能有 5925 到 31097 人有资格并愿意捐献。我们的研究结果表明,允许在即将死亡时进行捐赠,并将器官捐赠纳入临终规划,可以显著减少国家的肾脏等待名单,同时为更多的捐赠者提供机会,给予这个礼物。

相似文献

1
Potential yield of imminent death kidney donation.潜在的濒死期供肾的产量。
Am J Transplant. 2018 Feb;18(2):486-491. doi: 10.1111/ajt.14524. Epub 2017 Nov 11.
2
The UNOS OPTN Waiting List and Donor Registry: 1988-1996.器官共享联合网络(UNOS)等待名单与捐赠者登记处:1988 - 1996年
Clin Transpl. 1996:69-90.
3
Age, gender, race, and associations with kidney failure following living kidney donation.年龄、性别、种族以及与活体肾移植后肾衰竭的关联。
Transplant Proc. 2008 Jun;40(5):1337-40. doi: 10.1016/j.transproceed.2008.03.104.
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Am J Transplant. 2015 May;15(5):1187-91. doi: 10.1111/ajt.13232. Epub 2015 Mar 31.
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Clin Transplant. 2006 Nov-Dec;20(6):719-24. doi: 10.1111/j.1399-0012.2006.00541.x.
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International Travel for Living Donor Kidney Donation: A Proposal for Focused Screening of Vulnerable Groups.国际活体供肾捐赠旅行:脆弱群体有针对性筛查的建议。
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Views of US Voters on Compensating Living Kidney Donors.美国选民对活体肾脏捐献者补偿的看法。
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The UNOS OPTN waiting list and donor registry.器官共享联合网络(UNOS)的器官分配等待名单及捐赠者登记系统。
Clin Transpl. 1998:73-90.
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Assessment of living kidney donors and adherence to national live donor guidelines in the UK.英国对活体肾捐献者的评估以及对国家活体供者指南的遵循情况。
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引用本文的文献

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Do Patients Think it's Worth Waiting for a Kidney? Evidence from a Discrete-Choice Experiment.患者认为等待肾脏移植是否值得?来自离散选择实验的证据。
Patient. 2025 Sep 4. doi: 10.1007/s40271-025-00763-5.
2
Moral Injury Among Transplant Providers: Evaluating the Effects of Training in End-of-Life Counseling.移植医护人员的道德伤害:评估临终咨询培训的效果。
Kans J Med. 2023 Dec 31;16(3):324-327. doi: 10.17161/kjm.vol16.21171. eCollection 2023.

本文引用的文献

1
The case against imminent death donation.反对即刻死亡捐赠的理由。
Curr Opin Organ Transplant. 2017 Apr;22(2):184-188. doi: 10.1097/MOT.0000000000000389.
2
Long-Term Outcomes and Discard Rate of Kidneys by Decade of Extended Criteria Donor Age.按延长标准供者年龄的十年划分的长期结局和肾脏废弃率。
Clin J Am Soc Nephrol. 2017 Feb 7;12(2):323-331. doi: 10.2215/CJN.06550616. Epub 2016 Dec 15.
3
Kidney Donation Before Imminent Circulatory Death.心脏停跳前的肾脏捐献
Am J Kidney Dis. 2016 Oct;68(4):515-517. doi: 10.1053/j.ajkd.2016.04.013. Epub 2016 May 26.
4
Does pre-emptive transplantation versus post start of dialysis transplantation with a kidney from a living donor improve outcomes after transplantation? A systematic literature review and position statement by the Descartes Working Group and ERBP.预先移植与透析开始后从活体供者移植肾脏,哪一种能改善移植后的结局?笛卡尔工作组和 ERBP 的系统文献回顾和立场声明。
Nephrol Dial Transplant. 2016 May;31(5):691-7. doi: 10.1093/ndt/gfv378. Epub 2015 Nov 12.
5
A Cost-Benefit Analysis of Government Compensation of Kidney Donors.政府对肾脏捐赠者的补偿成本效益分析。
Am J Transplant. 2016 Mar;16(3):877-85. doi: 10.1111/ajt.13490. Epub 2015 Oct 16.
6
Kidney Transplantation From Elderly Donor.老年供体肾移植
Transplant Proc. 2015 Jun;47(5):1309-11. doi: 10.1016/j.transproceed.2015.04.015.
7
AST/ASTS workshop on increasing organ donation in the United States: creating an "arc of change" from removing disincentives to testing incentives.AST/ASTS 工作组会议:提高美国器官捐献率——消除障碍并建立激励机制,打造“改变之弧”。
Am J Transplant. 2015 May;15(5):1173-9. doi: 10.1111/ajt.13233. Epub 2015 Mar 31.
8
HIV-positive-to-HIV-positive kidney transplantation--results at 3 to 5 years.人类免疫缺陷病毒阳性患者之间的肾移植——3至5年的结果
N Engl J Med. 2015 Feb 12;372(7):613-20. doi: 10.1056/NEJMoa1408896.
9
Consensus conference on best practices in live kidney donation: recommendations to optimize education, access, and care.活体肾捐献最佳实践共识会议:优化教育、准入和护理的建议。
Am J Transplant. 2015 Apr;15(4):914-22. doi: 10.1111/ajt.13173. Epub 2015 Feb 3.
10
Abandoning the dead donor rule? A national survey of public views on death and organ donation.摒弃死亡器官捐献者规则?一项关于公众对死亡及器官捐献看法的全国性调查。
J Med Ethics. 2015 Apr;41(4):297-302. doi: 10.1136/medethics-2014-102229. Epub 2014 Sep 26.