Yang M, Hu F B, Giovannucci E L, Stampfer M J, Willett W C, Fuchs C S, Wu K, Bao Y
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Eur J Clin Nutr. 2016 Mar;70(3):333-7. doi: 10.1038/ejcn.2015.66. Epub 2015 May 6.
BACKGROUND/OBJECTIVES: Increasing nut consumption has been associated with reduced risk of obesity and type II diabetes, the risk factors for colorectal cancer. However, the association between nut consumption and colorectal cancer risk is unclear. We aimed to examine the association of long-term nut consumption with risk of colorectal cancer.
SUBJECTS/METHODS: We prospectively followed 75,680 women who were free of cancer at baseline in the Nurses' Health Study, and examined the association between nut consumption and colorectal cancer risk. Nut consumption was assessed at baseline and updated every 2-4 years. Relative risks (RRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards models.
During 2,103,037 person-years of follow-up, we identified 1503 colorectal cancer cases. After adjustment for other known or suspected risk factors, women who consumed nuts 2 or more times per week (that is, ⩾ 56 g per week) had a 13% lower risk of colorectal cancer compared with those who rarely consumed nuts, but the association was not statistically significant (RR: 0.87; 95% CI: 0.72-1.05; P-trend: 0.06). No association was observed for peanut butter.
In this large prospective cohort of women, frequent nut consumption was not significantly associated with colorectal cancer risk after adjusting for other risk factors.
背景/目的：增加坚果摄入量与肥胖和II型糖尿病（结直肠癌的风险因素）风险降低相关。然而，坚果摄入量与结直肠癌风险之间的关联尚不清楚。我们旨在研究长期食用坚果与结直肠癌风险之间的关联。
对象/方法：我们对护士健康研究中75680名基线时无癌症的女性进行了前瞻性随访，研究坚果摄入量与结直肠癌风险之间的关联。在基线时评估坚果摄入量，并每2 - 4年更新一次。使用Cox比例风险模型估计相对风险（RRs）和95%置信区间（95% CIs）。
在2103037人年的随访期间，我们确定了1503例结直肠癌病例。在对其他已知或疑似风险因素进行调整后，每周食用坚果2次或更多次（即每周≥56克）的女性与很少食用坚果的女性相比，患结直肠癌的风险降低了13%，但该关联无统计学意义（RR：0.87；95% CI：0.72 - 1.05；P趋势：0.06）。未观察到花生酱与结直肠癌之间的关联。
在这个大型女性前瞻性队列中，在调整其他风险因素后，频繁食用坚果与结直肠癌风险无显著关联。
