自身抗体对某些Vk基因家族的偏向性使用及其在自身免疫小鼠中的多态性。

Biased usage of certain Vk gene families by autoantibodies and their polymorphism in autoimmune mice.

作者信息

Kasturi K, Monestier M, Mayer R, Bona C

机构信息

Department of Microbiology, Mount Sinai Medical Center, New York, NY 10029.

出版信息

Mol Immunol. 1988 Feb;25(2):213-9. doi: 10.1016/0161-5890(88)90070-3.

DOI:10.1016/0161-5890(88)90070-3

PMID:2897624

Abstract

Of 79 hybridomas derived from stimulated or unstimulated autoimmune disease prone mouse strains, secreting autoantibodies of various specificities more than 65% use V genes from five Vk families, namely, Vk1, Vk4, Vk8, Vk10 and Vk19. Restriction fragment length polymorphism (RFLP) analysis of genomic DNAs from autoimmune prone mouse strains, tight skin, NZB and SJL show marked differences in the polymorphism of the Vk1, Vk10 and Vk19 gene families.

摘要

在源自受刺激或未受刺激的易患自身免疫性疾病小鼠品系的79个杂交瘤中，分泌各种特异性自身抗体的杂交瘤中超过65%使用来自五个Vk基因家族的V基因，即Vk1、Vk4、Vk8、Vk10和Vk19。对易患自身免疫性疾病的小鼠品系、紧皮小鼠、NZB和SJL的基因组DNA进行的限制性片段长度多态性（RFLP）分析显示，Vk1、Vk10和Vk19基因家族的多态性存在显著差异。