Sun Yintao, Deming Timothy J
ACS Macro Lett. 2019 May 21;8(5):553-557. doi: 10.1021/acsmacrolett.9b00269. Epub 2019 Apr 30.
Diblock, triblock, and pentablock copolypeptides were designed and prepared for formation of polyion complex hydrogels in aqueous media. Increasing the number of block segments was found to allow formation of hydrogels with substantially enhanced stiffness at equivalent concentrations. Use of similar length ionic segments also allowed mixing of different block architectures to fine-tune hydrogel properties. The pentablock hydrogels possess a promising combination of high stiffness, rapid self-healing properties, and cell compatible surface chemistry that makes them promising candidates for applications requiring injectable or printable hydrogel scaffolds.
设计并制备了二嵌段、三嵌段和五嵌段共多肽，用于在水性介质中形成聚离子复合水凝胶。研究发现，增加嵌段片段的数量能够在等效浓度下形成具有显著增强硬度的水凝胶。使用长度相似的离子片段还能混合不同的嵌段结构，以微调水凝胶的性能。五嵌段水凝胶具有高硬度、快速自愈性能和细胞相容性表面化学的理想组合，这使其成为需要可注射或可打印水凝胶支架的应用的有前途的候选材料。
