Silva Anna Larissa Cortês da, Ribeiro Karla Danielly da Silva, Melo Larisse Rayanne Miranda de, Bezerra Dalila Fernandes, Queiroz Jaluza Luana Carvalho de, Lima Mayara Santa Rosa, Pires Jeane Franco, Bezerra Danielle Soares, Osório Mônica Maria, Dimenstein Roberto
Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brasil.
UFRN, Santa Cruz, RN, Brasil.
Rev Paul Pediatr. 2017 Apr-Jun;35(2):158-164. doi: 10.1590/1984-0462/;2017;35;2;00015.
To determine the alpha-tocopherol concentration in breast milk at different periods of lactation and to estimate the possible supply of vitamin E to the infant.
A longitudinal observational study was carried out with 100 mothers at University Hospital Ana Bezerra (HUAB), at Universidade Federal do Rio Grande do Norte, in Santa Cruz (RN), Northeast Brazil. Samples of colostrum (n=100), transitional milk (n=77), and mature milk (n=63) were collected. Alpha-tocopherol was analyzed by high-performance liquid chromatography. Vitamin supply to the newborn was estimated by comparing the nutritional requirement of vitamin E (4 mg/day) with the potential daily intake of milk.
The mean alpha-tocopherol concentration found in colostrum, transitional, and mature milk was 40.5±15.0 µmol/L, 13.9±5.2 µmol/L, and 8.0±3.8 µmol/L, respectively (p<0.001). The possible effect of these milks offered to the infant 6.2 mg/day of vitamin E in colostrum, 4.7 mg/day in transitional milk, and 2.7 mg/day in mature milk (p<0.0001), shows that only the mature milk did not guarantee the recommended quantity of this vitamin.
Alpha-tocopherol levels in human milk decrease through the progression of lactation, and the possible intake of colostrum and transitional milk met the nutritional requirement of the infant. Mature milk may provide smaller amounts of vitamin E. Thus, it is important to study the factors that are associated with such low levels.
测定哺乳期不同阶段母乳中α-生育酚的浓度，并估计婴儿可能获得的维生素E供应量。
在巴西东北部圣克鲁斯（RN）的北里奥格兰德联邦大学安娜·贝泽拉大学医院（HUAB）对100名母亲进行了一项纵向观察研究。收集了初乳（n = 100）、过渡乳（n = 77）和成熟乳（n = 63）样本。通过高效液相色谱法分析α-生育酚。通过将维生素E的营养需求量（4毫克/天）与每日潜在的乳汁摄入量进行比较，来估计新生儿的维生素供应量。
初乳、过渡乳和成熟乳中α-生育酚的平均浓度分别为40.5±15.0微摩尔/升、13.9±5.2微摩尔/升和8.0±3.8微摩尔/升（p<0.001）。这些乳汁提供给婴儿的维生素E量分别为初乳中6.2毫克/天、过渡乳中4.7毫克/天、成熟乳中2.7毫克/天（p<0.0001），这表明只有成熟乳不能保证该维生素的推荐摄入量。
随着哺乳期的进展，人乳中α-生育酚水平下降，初乳和过渡乳的可能摄入量满足了婴儿的营养需求。成熟乳可能提供较少的维生素E。因此，研究与如此低水平相关的因素很重要。
