Deng Han-Bing, Tam Tony, Zee Benny Chung-Ying, Chung Roger Yat-Nork, Su Xuefen, Jin Lei, Chan Ta-Chien, Chang Ly-Yun, Yeoh Eng-Kiong, Lao Xiang Qian
Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Department of Sociology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Sleep. 2017 Oct 1;40(10). doi: 10.1093/sleep/zsx130.
The metabolic impact of inadequate sleep has not been determined in healthy individuals outside laboratories. This study aims to investigate the impact of sleep duration on five metabolic syndrome components in a healthy adult cohort.
A total of 162121 adults aged 20-80 years (men 47.4%) of the MJ Health Database, who were not obese and free from major diseases, were recruited and followed up from 1996 to 2014. Sleep duration and insomnia symptoms were assessed by a self-administered questionnaire. Incident cases of five metabolic syndrome components were identified by follow-up medical examinations. Cox proportional hazard ratios (HRs) were calculated for three sleep duration categories "< 6 hours/day (short)," "6-8 hours/day (regular)," and "> 8 hours/day (long)" with adjustment for potential confounding factors. Analyses were stratified by insomnia symptoms to assess whether insomnia symptoms modified the association between sleep duration and metabolic syndrome.
Compared to regular sleep duration, short sleep significantly (p < .001) increased the risk for central obesity by 12% (adjusted HR 1.12 [1.07-1.17]), for elevated fasting glucose by 6% (adjusted HR 1.06 [1.03-1.09]), for high blood pressure by 8% (adjusted HR 1.08 [1.04-1.13]), for low high-density lipoprotein-cholesterol by 7% (adjusted HR 1.07 [1.03-1.11]), for hypertriglyceridemia by 9% (adjusted HR 1.09 [1.05-1.13]), and for metabolic syndrome by 9% (adjusted HR 1.09 [1.05-1.13]). Long sleep decreased the risk of hypertriglyceridemia (adjusted HR 0.89 [0.84-0.94]) and metabolic syndrome (adjusted HR 0.93 [0.88-0.99]). Insomnia symptoms did not modify the effects of sleep duration.
Sleep duration may be a significant determinant of metabolic health.
在实验室以外的健康个体中，睡眠不足对新陈代谢的影响尚未明确。本研究旨在调查睡眠时间对一个健康成年队列中代谢综合征五个组成部分的影响。
从MJ健康数据库中招募了162121名年龄在20 - 80岁之间的成年人（男性占47.4%），这些人不肥胖且没有重大疾病，并于1996年至2014年进行随访。通过自我填写问卷评估睡眠时间和失眠症状。通过后续体检确定代谢综合征五个组成部分的发病情况。计算了三个睡眠时间类别（“每天<6小时（短睡眠）”、“每天6 - 8小时（正常睡眠）”和“每天>8小时（长睡眠）”）的Cox比例风险比（HRs），并对潜在混杂因素进行了调整。分析按失眠症状进行分层，以评估失眠症状是否改变了睡眠时间与代谢综合征之间的关联。
与正常睡眠时间相比，短睡眠显著（p <.001）使中心性肥胖风险增加12%（调整后HR 1.12 [1.07 - 1.17]），空腹血糖升高风险增加6%（调整后HR 1.06 [1.03 - 1.09]），高血压风险增加8%（调整后HR 1.08 [1.04 - 1.13]），高密度脂蛋白胆固醇降低风险增加7%（调整后HR 1.07 [1.03 - 1.11]），高甘油三酯血症风险增加9%（调整后HR 1.09 [1.05 - 1.13]），代谢综合征风险增加9%（调整后HR 1.09 [1.05 - 1.13]）。长睡眠降低了高甘油三酯血症风险（调整后HR 0.89 [0.84 - 0.94]）和代谢综合征风险（调整后HR 0.93 [0.88 - .99]）。失眠症状并未改变睡眠时间的影响。
睡眠时间可能是代谢健康的一个重要决定因素。
