Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Students' Scientific Research Center (SSRC), Tehran University of Medical Science, Tehran, Iran.
PLoS One. 2024 Jul 15;19(7):e0307120. doi: 10.1371/journal.pone.0307120. eCollection 2024.
Sleep duration has been suggested to be associated with hypertension (HTN). However, evidence of the nature of the relationship and its direction has been inconsistent. Therefore, we performed a meta-analysis to assess the relationship between sleep duration and risk of HTN incidence, and to distinguish more susceptible populations.
PubMed, Embase, Scopus, Web of Science, and ProQuest were searched from January 2000 to May 2023 for cohort studies comparing short and long sleep durations with 7-8 hours of sleep for the risk of HTN incidence. Random-effect model (the DerSimonian-Laird method) was applied to pool risk ratios (RR) and 95% confidence interval (CI).
We included sixteen studies ranging from 2.4 to 18 years of follow-up duration evaluating HTN incidence in 1,044,035 people. Short sleep duration was significantly associated with a higher risk of developing HTN (HR: 1.07, 95% CI: 1.06-1.09). The association was stronger when the sleep duration was less than 5 hours (HR: 1.11, 95% CI: 1.08-1.14). In contrast to males, females (HR: 1.07, 95% CI: 1.04-1.09) were more vulnerable to developing HTN due to short sleep duration. No significant difference between different follow-up durations and age subgroups was observed. Long sleep duration was not associated with an increased incidence of HTN.
Short sleep duration was associated with higher risk of HTN incidence, however, there was no association between long sleep duration and incidence of HTN. These findings highlight the importance of implementing target-specific preventive and interventional strategies for vulnerable populations with short sleep duration to reduce the risk of HTN.
已有研究表明，睡眠时间与高血压（HTN）有关。然而，关于两者之间关系的本质及其方向的证据一直不一致。因此，我们进行了一项荟萃分析，以评估睡眠时间与 HTN 发病风险之间的关系，并区分更易感的人群。
从 2000 年 1 月至 2023 年 5 月，我们检索了 PubMed、Embase、Scopus、Web of Science 和 ProQuest 数据库，以纳入比较 7-8 小时睡眠时间与短（<7 小时）长（>8 小时）睡眠时间与 HTN 发病风险的队列研究。应用随机效应模型（DerSimonian-Laird 方法）汇总风险比（RR）和 95%置信区间（CI）。
我们纳入了 16 项研究，随访时间从 2.4 年到 18 年不等，共评估了 1044035 人的 HTN 发病情况。短睡眠时间与发生 HTN 的风险升高显著相关（RR：1.07，95%CI：1.06-1.09）。当睡眠时间少于 5 小时时，这种关联更强（RR：1.11，95%CI：1.08-1.14）。与男性相比，女性（RR：1.07，95%CI：1.04-1.09）由于短睡眠时间而更容易发生 HTN。不同随访时间和年龄亚组之间未见显著差异。长睡眠时间与 HTN 的发病率增加无关。
短睡眠时间与 HTN 发病风险升高相关，而长睡眠时间与 HTN 发病风险无关。这些发现强调了针对短睡眠时间易感人群实施针对性预防和干预策略的重要性，以降低 HTN 的风险。
