Zhang Hao, Wang Guangchao, Ding Chen, Liu Peng, Wang Renkai, Ding Wenbin, Tong Dake, Wu Dajiang, Li Cheng, Wei Qiang, Zhang Xin, Li Di, Liu Peizhao, Cui Haochen, Tang Hao, Ji Fang
Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China.
Department of General Sugery, Changhai Hospital, Second Military Medical University, Shanghai, China.
Oncotarget. 2017 Jun 27;8(37):61687-61697. doi: 10.18632/oncotarget.18671. eCollection 2017 Sep 22.
Deregulated expression of circular RNA (circRNA) has been determined to be important in carcinogenesis and progression; however, in the most common type of primary malignant bone tumor osteosarcoma, the roles of circRNA in cancer development still remain to be elucidated. Here, we found that circRNA UBAP2 (circUBAP2) expression is significantly increased in human osteosarcoma tissues as compared to those in matched controls. Increased circUBAP2 expression was significantly correlated with human osteosarcoma progression and prognosis. Furthermore, increased circUBAP2 could promote osteosarcoma growth and inhibit apoptosis both and . Mechanistically, circUBAP2 was found to inhibit the expression of microRNA-143 (miR-143), thus enhancing the expression and function of anti-apoptotic Bcl-2, which is a direct target of miR-143. Together, our results suggest the roles of circUBAP2 in osteosarcoma development and implicate its potential in prognosis prediction and cancer therapy.
环状RNA（circRNA）的失调表达已被确定在肿瘤发生和进展中起重要作用；然而，在最常见的原发性恶性骨肿瘤骨肉瘤中，circRNA在癌症发展中的作用仍有待阐明。在此，我们发现与配对对照相比，circRNA UBAP2（circUBAP2）在人骨肉瘤组织中的表达显著增加。circUBAP2表达增加与人类骨肉瘤进展和预后显著相关。此外，circUBAP2增加可促进骨肉瘤生长并抑制细胞凋亡。机制上，发现circUBAP2抑制微小RNA-143（miR-143）的表达，从而增强抗凋亡蛋白Bcl-2的表达和功能，而Bcl-2是miR-143的直接靶点。总之，我们的结果表明circUBAP2在骨肉瘤发展中的作用，并暗示其在预后预测和癌症治疗中的潜力。
