Chen Zhong, Sun Yu, Xu Zhenxiong, Xu Junnv, Li Jingjie, Yan Mengdan, Li Jing, Jin Tianbo, Lin Haifeng
Department of Thoracic Surgery, Second People's Hospital of Hainan Province, Hainan, 572200, China.
Department of General Surgery, Second People's Hospital of Hainan Province, Hainan, 572200, China.
Oncotarget. 2017 Jun 19;8(40):67723-67731. doi: 10.18632/oncotarget.18574. eCollection 2017 Sep 15.
We explored the association between single nucleotide polymorphisms (SNPs) in and liver cancer risk. Thirteen SNPs were genotyped in 473 cases and 564 controls. Genetic model, linkage disequilibrium, and haplotype analyses were performed to evaluate the association between SNPs and liver cancer risk. We found that rs6713088 (G allele: odds ratio [OR] = 1.27, 95% confidence interval [CI]: 1.07-1.52, = 0.007; GG vs. CC: OR = 1.49, 95% CI: 1.02-2.1, = 0.038), rs843711 (T allele: OR = 1.29, 95% CI: 1.09-1.54, = 0.004; TT vs. CC: OR = 1.62, 95% CI: 1.13-2.31, = 0.008), rs843706 (A allele: OR = 1.30, 95% CI: 1.09-1.55, = 0.003; AA vs. CC: OR = 1.62, 95% CI: 1.13-2.31, = 0.008), and rs843645 (GG vs. AG: OR = 1.40, 95% CI: 1.07-1.82, = 0.014) were associated with an increased risk of liver cancer. In contrast, rs1682111 (A allele: OR = 0.77, 95% CI: 0.640-0.94, = 0.007; AT vs. TT: OR = 0.69, 95% CI: 0.53-0.91, = 0.007), rs843720 (additive model: OR = 0.82, 95% CI: 0.68-1.00, = 0.049), ATATCGCC and CG haplotypes (OR = 0.76, 95% CI: 0.62-0.92, = 0.006; OR = 0.78, 95% CI: 0.65-0.93, = 0.006, respectively) were significantly decreased liver cancer risk. Our results confirmed that rs6713088, rs843645, rs843711 and rs843706 were significantly increased liver cancer risk, but rs1682111, rs843720 and haplotypes (ATATCGCC and CG) were significantly decreased liver cancer risk in a Han Chinese population.
我们探究了[基因名称]中的单核苷酸多态性（SNP）与肝癌风险之间的关联。对473例病例和564例对照进行了13个SNP的基因分型。进行了遗传模型、连锁不平衡和单倍型分析，以评估[基因名称]SNP与肝癌风险之间的关联。我们发现，rs6713088（G等位基因：比值比[OR]=1.27，95%置信区间[CI]：1.07 - 1.52，P = 0.007；GG与CC相比：OR = 1.49，95% CI：1.02 - 2.1，P = 0.038）、rs843711（T等位基因：OR = 1.29，95% CI：1.09 - 1.54，P = 0.004；TT与CC相比：OR = 1.62，95% CI：1.13 - 2.31，P = 0.008）、rs843706（A等位基因：OR = 1.30，95% CI：1.09 - 1.55，P = 0.003；AA与CC相比：OR = 1.62，95% CI：1.13 - 2.31，P = 0.008）以及rs843645（GG与AG相比：OR = 1.40，95% CI：1.07 - 1.82，P = 0.014）与肝癌风险增加相关。相反，rs1682111（A等位基因：OR = 0.77，95% CI：0.640 - 0.94，P = 0.007；AT与TT相比：OR = 0.69，95% CI：0.53 - 0.91，P = 0.007）、rs843720（加性模型：OR = 0.82，95% CI：0.68 - 1.00，P = 0.049）、ATATCGCC和CG单倍型（OR分别为0.76，95% CI：0.62 - 0.92，P = 0.006；OR = 0.78，95% CI：0.65 - 0.93，P = 0.006）与肝癌风险显著降低相关。我们的结果证实，在汉族人群中，rs6713088、rs843645、rs843711和rs843706显著增加肝癌风险，但rs1682111、rs843720和单倍型（ATATCGCC和CG）显著降低肝癌风险。
