Zhang Fuli, Zhang Yan, Deng Zhiping, Xu Pengcheng, Zhang Xiyang, Jin Tianbo, Liu Qiufang
Department of Oncology Surgery, Traditional Chinese Medicine Hospital of Xi'an, Xi'an, Shaanxi 710021, China.
Department of Breast Surgery, Tumor Hospital of Shaanxi Province, Xi'an 710061, China.
Oncotarget. 2016 Dec 27;7(52):86704-86712. doi: 10.18632/oncotarget.13495.
We performed a case-control study to investigate the associations between seven single nucleotide polymorphisms (SNPs) in the acylphosphatase 2 (ACYP2) gene and breast cancer (BC) risk in a Han Chinese population. There were 183 BC cases and 195 healthy controls included in the study. The SNPs were genotyped using the Sequenom MassARRAY platform. Logistic regression (adjusted for age group, body mass index [BMI], and menopause status), was used to evaluate the associations between the various genotypes and BC risk. Statistical analysis revealed that rs12621038 was associated with a decreased risk of BC in the allele (T vs. C: odds ratio [OR] = 0.71, 95% confidence interval [95% CI] = 0.52-0.94; p = 0.016), homozygous (TT vs. CC: OR = 0.47, 95% CI = 0.24-0.85; p = 0.014), dominant (OR = 0.62; 95% CI = 0.40-0.96; p = 0.032), and additive (OR = 0.68; 95% CI = 0.50-0.92; p = 0.012) models. In addition, we found that rs1682111 and rs17045754 were associated with the risk of BC and correlated with recurrence, and that rs6713088 correlated with tumor size. In sum, our findings reveal significant associations between SNPs in the ACYP2 gene and BC risk in a Han Chinese population.
我们开展了一项病例对照研究，以调查酰基磷酸酶2（ACYP2）基因中的7个单核苷酸多态性（SNP）与中国汉族人群乳腺癌（BC）风险之间的关联。该研究纳入了183例BC病例和195名健康对照。使用Sequenom MassARRAY平台对SNP进行基因分型。采用逻辑回归分析（根据年龄组、体重指数[BMI]和绝经状态进行调整）来评估不同基因型与BC风险之间的关联。统计分析显示，rs12621038在等位基因（T与C：优势比[OR]=0.71，95%置信区间[95%CI]=0.52 - 0.94；p = 0.016）、纯合子（TT与CC：OR = 0.47，95%CI = 0.24 - 0.85；p = 0.014）、显性（OR = 0.62；95%CI = 0.40 - 0.96；p = 0.032）和加性（OR = 0.68；95%CI = 0.50 - 0.92；p = 0.012）模型中与BC风险降低相关。此外，我们发现rs1682111和rs17045754与BC风险相关且与复发有关，rs6713088与肿瘤大小相关。总之，我们的研究结果揭示了ACYP2基因中的SNP与中国汉族人群BC风险之间存在显著关联。
