炎症标志物以及一氧化氮在……过程中对血小板活化的影响。
Markers of inflammation and influence of nitric oxide on platelet activation in the course of .
作者信息
Gawrońska Beata, Matowicka-Karna Joanna, Kralisz Maciej, Kemona Halina
机构信息
Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Białystok, Poland.
Department of Internal Diseases and Gastroenterology, The Sniadecki Regional Hospital in Bialystok, Białystok, Poland.
出版信息
Oncotarget. 2017 Jul 12;8(40):68108-68114. doi: 10.18632/oncotarget.19202. eCollection 2017 Sep 15.
Ulcerative colitis is a non-specific inflammatory bowel disease of unknown etiology. We investigated whether severe form of ulcerative colitis may lead to increased number of platelets, changes in platelet parameters and their activation. To address our objectives, we measured concentrations of nitric oxide and markers of inflammation. We found increased number of low-volume platelets in a group of affected patients. However, their activity was not as high as expected. In addition to that we observed eight times higher concentration of nitric oxide in patients suffering from ulcerative colitis than in healthy individuals. Besides, severe form of the disease manifested itself with increased concentrations of interleukine 6, matrix metalloproteinase-9 and neopterin. Based on the results we propose that high amounts of nitric oxide inhibit platelet activation in severe form of ulcerative colitis. Moreover, our observations regarding interleukine 6, matrix metalloproteinase-9 and neopterin suggest that they may become useful markers of active form of ulcerative colitis.
溃疡性结肠炎是一种病因不明的非特异性炎症性肠病。我们研究了重度溃疡性结肠炎是否会导致血小板数量增加、血小板参数变化及其激活。为了实现我们的目标，我们测量了一氧化氮浓度和炎症标志物。我们发现一组患病患者中低体积血小板数量增加。然而，它们的活性并不像预期的那么高。除此之外，我们观察到溃疡性结肠炎患者体内一氧化氮浓度比健康个体高八倍。此外，该疾病的重度形式表现为白细胞介素6、基质金属蛋白酶-9和新蝶呤浓度升高。基于这些结果，我们提出大量一氧化氮会抑制重度溃疡性结肠炎中血小板的激活。此外，我们关于白细胞介素6、基质金属蛋白酶-9和新蝶呤的观察结果表明，它们可能成为溃疡性结肠炎活动形式的有用标志物。
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