Chen Guanglei, Zhang Hao, Sun Lisha, Jiang Yanlin, Xu Zhen, Gu Huizi, Xu Hong, Yang Jie, Wang Yining, Xu Tiantian, Zhang Yingchao, Liu Caigang
Department of Breast Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Department of Surgical Oncology, The First Hospital of China Medical University, Shenyang 110013, China.
Oncotarget. 2017 Aug 2;8(40):68675-68680. doi: 10.18632/oncotarget.19824. eCollection 2017 Sep 15.
Previous studies showed that glutathione S-transferase Pi 1 (GSTP1) is a critical metabolic driver that is heightened specifically in triple negative breast cancer (TNBC) and drives breast cancer pathogenicity. This study focuses on investigating the relationship between the expression of the GSTP1 protein and TNBC metastasis and prognosis in China.
Chi-square and Fisher's exact tests showed that tumor size (P=0.023) and clinical stage (P=0.049) were significantly associated with GSTP1 expression. Patients with high GSTP1 expression exhibited an improved survival rate compared with patients with low GSTP1 expression, but the difference was not statistically significant (P=0.437). On multivariate analysis, clinical stage proved to be an independent prognostic factor for survival in breast cancer.
A total of 175 patients with histologically confirmed TNBC, who also underwent radical surgery between January 2008 and November 2011 at the Liaoning Cancer Hospital, were enrolled. Immunohistochemistry was used to detect GSTP1 expression in breast cancer tissue from 175 patients. The correlations between GSTP1 expression and other parameters were evaluated using the Chi-square and Fisher's exact tests. Univariate and multivariate Cox regression analyses were performed to assess independent prognostic factors for survival. Associations of GSTP1 expression with clinical stage and prognosis were analyzed using Kaplan-Meier survival curves.
Tumors with high GSTP1 protein expression were independently associated with low clinical stages in TNBC patients in China. The expression of the GSTP1 protein may be a novel prognosis marker for TNBC patients in China.
先前的研究表明，谷胱甘肽S-转移酶Pi 1（GSTP1）是一种关键的代谢驱动因子，在三阴性乳腺癌（TNBC）中特异性升高，并驱动乳腺癌的致病性。本研究聚焦于探究中国人群中GSTP1蛋白表达与TNBC转移及预后之间的关系。
卡方检验和Fisher精确检验显示，肿瘤大小（P = 0.023）和临床分期（P = 0.049）与GSTP1表达显著相关。与低GSTP1表达的患者相比，高GSTP1表达的患者生存率有所提高，但差异无统计学意义（P = 0.437）。多因素分析表明，临床分期是乳腺癌生存的独立预后因素。
选取2008年1月至2011年11月在辽宁省肿瘤医院接受根治性手术的175例经组织学确诊的TNBC患者。采用免疫组织化学法检测175例患者乳腺癌组织中GSTP1的表达。使用卡方检验和Fisher精确检验评估GSTP1表达与其他参数之间的相关性。进行单因素和多因素Cox回归分析以评估生存的独立预后因素。使用Kaplan-Meier生存曲线分析GSTP1表达与临床分期及预后的关联。
在中国TNBC患者中，GSTP1蛋白高表达的肿瘤与低临床分期独立相关。GSTP1蛋白表达可能是中国TNBC患者的一种新的预后标志物。
