Talavera-Adame Dodanim, Newman Daniella, Newman Nathan
American Advanced Medical Corp. (Private Practice), Beverly Hills, CA.
Western University of Health Sciences, Pomona, CA, USA.
Stem Cells Cloning. 2017 Aug 31;10:11-19. doi: 10.2147/SCCAA.S138150. eCollection 2017.
The prevalence of androgenic alopecia (AGA) increases with age and it affects both men and women. Patients diagnosed with AGA may experience decreased quality of life, depression, and feel self-conscious. There are a variety of therapeutic options ranging from prescription drugs to non-prescription medications. Currently, AGA involves an annual global market revenue of US$4 billion and a growth rate of 1.8%, indicating a growing consumer market. Although natural and synthetic ingredients can promote hair growth and, therefore, be useful to treat AGA, some of them have important adverse effects and unknown mechanisms of action that limit their use and benefits. Biologic factors that include signaling from stem cells, dermal papilla cells, and platelet-rich plasma are some of the current therapeutic agents being studied for hair restoration with milder side effects. However, most of the mechanisms exerted by these factors in hair restoration are still being researched. In this review, we analyze the therapeutic agents that have been used for AGA and emphasize the potential of new therapies based on advances in stem cell technologies and regenerative medicine.
雄激素性脱发（AGA）的患病率随年龄增长而增加，且男女均可患病。被诊断为AGA的患者可能会经历生活质量下降、抑郁，并产生自我意识。从处方药到非处方药，有多种治疗选择。目前，AGA的全球年度市场收入为40亿美元，增长率为1.8%，表明消费市场在不断增长。尽管天然和合成成分可以促进头发生长，因此对治疗AGA有用，但其中一些成分有重要的副作用且作用机制不明，这限制了它们的使用和益处。包括来自干细胞、毛囊乳头细胞和富血小板血浆的信号传导等生物因素是目前正在研究的一些用于头发修复且副作用较小的治疗剂。然而，这些因素在头发修复中发挥作用的大多数机制仍在研究中。在本综述中，我们分析了已用于AGA的治疗剂，并强调基于干细胞技术和再生医学进展的新疗法的潜力。
