Cervantes Jessica, Perper Marina, Wong Lulu L, Eber Ariel E, Villasante Fricke Alexandra C, Wikramanayake Tongyu Cao, Jimenez Joaquin J
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
Department of Medicine, Brown University Alpert School of Medicine, Rhode Island Hospital, Providence, Rhode Island, USA.
Skin Appendage Disord. 2018 Jan;4(1):1-11. doi: 10.1159/000477671. Epub 2017 Jun 24.
Androgenetic alopecia (AGA) is a hair loss disorder affecting 80% of men and 50% of women throughout their lifetime. Therapies for AGA are limited and there is no cure. There is a high demand for hair restoration. Platelet-rich plasma (PRP), a treatment modality shown to promote wound healing, has also been explored as a treatment for AGA. This literature review was conducted to assess the effectiveness of PRP treatment for AGA. Twelve studies conducted from 2011 to 2017 were evaluated and summarized by study characteristics, mode of preparation, and treatment protocols. A total of 295 subjects were given PRP or control treatment in these studies, and evaluated for terminal hair density, hair quality, anagen/telogen hair ratio, keratinocyte proliferation, blood vessel density, etc. Some studies also provided subject self-assessment reports. Most of the studies reviewed showed effectiveness of PRP in increasing terminal hair density/diameter. Additional investigations are needed to determine the optimal treatment regimen for high efficacy of PRP in AGA.
雄激素性脱发（AGA）是一种脱发疾病，在一生中影响80%的男性和50%的女性。AGA的治疗方法有限且无法治愈。毛发修复的需求很高。富血小板血浆（PRP）是一种已被证明可促进伤口愈合的治疗方式，也已被探索用于AGA的治疗。进行这项文献综述以评估PRP治疗AGA的有效性。对2011年至2017年进行的12项研究按研究特征、制备方式和治疗方案进行了评估和总结。在这些研究中，共有295名受试者接受了PRP或对照治疗，并对终毛密度、毛发质量、生长期/休止期毛发比率、角质形成细胞增殖、血管密度等进行了评估。一些研究还提供了受试者自我评估报告。大多数综述研究表明PRP在增加终毛密度/直径方面有效。需要进一步研究以确定PRP在AGA中高效治疗的最佳治疗方案。
