Carolina Headache Institute, Durham, NC, USA.
Departments of Psychiatry and Anesthesiology, University of North Carolina, Chapel Hill, NC, USA.
Curr Pain Headache Rep. 2017 Oct 4;21(11):46. doi: 10.1007/s11916-017-0646-4.
Since up to 40.9% of reproductive aged women have migraine-and reproductive-aged women often reproduce-it is essential that we have good information and guidelines regarding proper treatment of migraine during pregnancy and lactation.
A review of articles published in the last year on the treatment of migraine during pregnancy and lactation found dishearteningly little. Nevertheless, this article will review the risk/safety information related to migraine treatment in both pregnancy and lactation, citing both new and less recent publications. There is little if any formal research is being carried out on pharmacotherapy for migraine that occurs during pregnancy or lactation. This is likely due to two issues: (1) neurology offers little training in female sex hormones, while gynecology is a surgical field; (2) there is the ever-present concern of litigation if any bad outcome occurs, yet there is no designation of "legally safe" that can be applied to a drug's use in pregnancy and lactation.
由于多达 40.9%的育龄妇女患有偏头痛，而育龄妇女往往会生育，因此我们必须掌握有关妊娠和哺乳期偏头痛适当治疗的良好信息和指南。
对去年发表的关于妊娠和哺乳期偏头痛治疗的文章进行回顾，发现令人沮丧的是，相关内容很少。尽管如此，本文仍将回顾与妊娠和哺乳期偏头痛治疗相关的风险/安全性信息，同时引用新的和较旧的出版物。对于妊娠或哺乳期发生的偏头痛的药物治疗，几乎没有进行任何正式的研究。这可能是由于两个问题：（1）神经病学在女性性激素方面的培训很少，而妇科是一个外科领域；（2）如果发生任何不良后果，总是存在诉讼的担忧，但对于在妊娠和哺乳期使用药物，没有“合法安全”的指定。
