Center for Birth Defects Research and Prevention, Massachusetts Department of Public Health, Boston, MA, USA.
Am J Obstet Gynecol. 2012 Mar;206(3):228.e1-8. doi: 10.1016/j.ajog.2011.11.019. Epub 2011 Dec 1.
We examined whether the use of nonsteroidal antiinflammatory drugs (NSAIDs) in early pregnancy was associated with a range of structural birth defects.
Data were from the National Birth Defects Prevention Study, a multisite population-based, case-control study of risk factors for birth defects.
Among women in the National Birth Defects Prevention Study, 22.6% reported the use of NSAIDs in the first trimester of pregnancy, most commonly ibuprofen, aspirin, and naproxen. Of the 29 defect groups that were examined, most were not associated with NSAID use. Small-to-moderate increased risks of some oral cleft groups, some neural tube defect groups, anophthalmia/microphthalmia, pulmonary valve stenosis, amniotic bands/limb body wall defects, and transverse limb deficiencies were associated with ibuprofen, aspirin, and naproxen exposure.
The use of NSAIDs in early pregnancy does not appear to be a major risk factor for birth defects, although there were a few moderate associations between NSAIDs and specific birth defects.
本研究旨在探讨妊娠早期使用非甾体抗炎药（NSAIDs）是否与多种结构出生缺陷相关。
该研究的数据来自于全国出生缺陷预防研究，这是一项多地点基于人群的出生缺陷危险因素病例对照研究。
在全国出生缺陷预防研究的女性中，22.6%报告在妊娠早期使用 NSAIDs，最常见的是布洛芬、阿司匹林和萘普生。在所检查的 29 个缺陷组中，大多数与 NSAID 使用无关。一些口腔裂组、一些神经管缺陷组、无眼/小眼症、肺动脉瓣狭窄、羊膜带/肢体壁缺陷和横肢缺陷与布洛芬、阿司匹林和萘普生暴露相关，其风险呈小至中度增加。
妊娠早期使用 NSAIDs 似乎不是出生缺陷的主要危险因素，但 NSAIDs 与某些特定出生缺陷之间存在一些中度关联。
