Salman F T, Adkins E S, Fonkalsrud E W
Division of Pediatric Surgery, UCLA School of Medicine.
J Pediatr Surg. 1988 May;23(5):439-43. doi: 10.1016/s0022-3468(88)80444-5.
Unilateral cryptorchidism is frequently accompanied by infertility. Uncertainty exists as to whether the infertility is a genetic effect or is related to an autoimmune reaction to the elevated testis. The effects of unilateral cryptorchidism were evaluated in 50 mice by surgically elevating the left testicle of 21-day-old mice into the abdomen (AT). A sham operation was performed on the left testicle of 50 control mice (SHT). The temperature of the abdominal testes measured 2.5 degrees C higher than the scrotal testes. The testes were removed from both sides at 1, 2, 3, 4 and 6 weeks postoperation. After testicular weights were recorded, seminiferous tubule diameters were measured, and germinal epithelium maturity was graded histologically using a modified Johnson testicular biopsy score. Progressive abnormal changes were seen in the contralateral descended testicles of AT as compared to SHT. By 3 weeks, though testicular weight changes were similar, mean seminiferous tubule diameter was smaller (P less than .001), and the germinal epithelium was less mature (P less than .001). These changes persisted through the sixth week. By changing the physiologic environment of one testicle, we have induced alterations in the histologic appearance of the contralateral testicle during the period of normal maturation.
单侧隐睾症常伴有不育。目前尚不确定不育是遗传效应还是与对升高的睾丸的自身免疫反应有关。通过手术将21日龄小鼠的左侧睾丸提升至腹腔（AT），对50只小鼠单侧隐睾症的影响进行了评估。对50只对照小鼠的左侧睾丸进行假手术（SHT）。测量发现腹腔内睾丸的温度比阴囊内睾丸高2.5摄氏度。在术后1、2、3、4和6周从两侧取出睾丸。记录睾丸重量后，测量生精小管直径，并使用改良的约翰逊睾丸活检评分对生精上皮成熟度进行组织学分级。与SHT相比，AT的对侧下降睾丸出现了渐进性异常变化。到3周时，尽管睾丸重量变化相似，但生精小管平均直径较小（P<0.001），生精上皮成熟度较低（P<0.001）。这些变化持续到第六周。通过改变一侧睾丸的生理环境，我们在正常成熟期间诱导了对侧睾丸组织学外观的改变。
