Department of Physics, Biophysics Group, Friedrich-Alexander-University Erlangen-Nuremberg, D-91052 Erlangen, Germany.
Cell Biol Int. 2018 Feb;42(2):132-138. doi: 10.1002/cbin.10879. Epub 2018 Jan 10.
Intermediate filaments (IFs) are one of the three types of cytoskeletal polymers that resist tensile and compressive forces in cells. They crosslink each other as well as with actin filaments and microtubules by proteins, which include desmin, filamin C, plectin, and lamin (A/C). Mutations in these proteins can lead to a wide range of pathologies, some of which exhibit mechanical failure of the skin, skeletal, or heart muscle.
中间丝（IFs）是细胞内抵抗拉伸和压缩力的三种细胞骨架聚合物之一。它们通过包括结蛋白、细丝蛋白 C、网蛋白和核纤层蛋白（A/C）在内的蛋白质与肌动蛋白丝和微管相互交联。这些蛋白质的突变可导致广泛的病理，其中一些表现为皮肤、骨骼或心肌的机械性衰竭。
