Pashen R L, Allen W R
J Reprod Fertil Suppl. 1979(27):499-509.
The effects of fetal gonadectomy on steroid production and the maintenance of pregnancy in the mare were studied. Removal of the fetal gonads resulted in an immediate fall in maternal plasma concentrations of conjugated and unconjugated oestrogens whereas progestagen levels remained unchanged. Hormone profiles in mares carrying sham-operated fetuses remained similar to those in unoperated control mares. Plasma levels of 13,14-dihydro-15-oxo-PGF-2 alpha (PGFM) were much lower, and uterine contractions weaker, during labour in mares carrying gonadectomized foals than in control mares. Pregnancy was maintained until parturition at term in the mares carrying gonadectomized fetuses. However, 3 of the 4 gonadectomized foals were dysmature and died during or soon after birth. The biosynthetic pathways involved in the production of oestrogens by the feto-placental unit and the possible role of oestrogens in fetal development in the pregnant mare are discussed.
研究了胎儿性腺切除术对母马类固醇生成及维持妊娠的影响。切除胎儿性腺导致母体血浆中结合型和非结合型雌激素浓度立即下降，而孕激素水平保持不变。携带假手术胎儿的母马的激素谱与未手术的对照母马相似。与对照母马相比，携带性腺切除胎儿的母马在分娩时血浆13,14-二氢-15-氧代-PGF-2α（PGFM）水平低得多，子宫收缩也较弱。携带性腺切除胎儿母马的妊娠维持至足月分娩。然而，4只性腺切除胎儿中有3只发育不成熟，在出生时或出生后不久死亡。本文讨论了胎儿-胎盘单位产生雌激素的生物合成途径以及雌激素在妊娠母马胎儿发育中的可能作用。
