Fletcher K, Cordiner J W, Macnab J C
Institute of Virology, University of Glasgow.
Dis Markers. 1986 Oct;4(3):219-29.
Punch biopsies were taken from patients with cervical intraepithelial neoplasia and the DNA was extracted and examined for sequences which hybridized to human cytomegalovirus DNA by Southern blotting analysis. Two biopsies out of 43 were found to contain DNA which hybridized to human cytomegalovirus DNA. In one biopsy DNA sequences were detected which contained four restriction sites colinear with those of the prototype strain AD169. Evidence of rearranged viral DNA sequences was also found.
对宫颈上皮内瘤变患者进行了打孔活检，提取DNA，并通过Southern印迹分析检测与人类巨细胞病毒DNA杂交的序列。43份活检样本中有两份被发现含有与人类巨细胞病毒DNA杂交的DNA。在一份活检样本中检测到的DNA序列含有四个与原型株AD169共线的限制性酶切位点。还发现了病毒DNA序列重排的证据。
