Kang Wenjing, Rusinek Cory, Bange Adam, Haynes Erin, Heineman William R, Papautsky Ian
Department of Electrical Engineering and Computing Systems, University of Cincinnati, Cincinnati, OH 45221-0030.
Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172.
Electroanalysis. 2017 Mar;29(3):686-695. doi: 10.1002/elan.201600679. Epub 2017 Jan 26.
In this work, we report on the determination of trace manganese (Mn) using cathodic stripping voltammetry (CSV) using a microfabricated sensor with a Pt thin-film working electrode. While an essential trace metal for human health, prolonged exposure to Mn tends to gradually impair our neurological system. The potential sources of Mn exposure make it necessary to monitor the concentration in various sample matrices. Previous work by us and others suggested CSV as an effective method for measuring trace Mn. The analytical performance metrics were characterized and optimized, leading to a calculated limit of detection (LOD) of 16.3 nM (0.9 ppb) in pH 5.5, 0.2 M acetate buffer. Further, we successfully validated Mn determination in surface water with ~90% accuracy and >97% precision as compared with ICP-MS "gold standard" measurement. Ultimately, with stable, accurate and precise electrochemical performance, this Pt sensor permits rapid monitoring of Mn in environmental samples, and could potentially be used for point-of-use measurements if coupled with portable instrumentation.
在本工作中，我们报告了使用带有铂薄膜工作电极的微制造传感器，通过阴极溶出伏安法（CSV）测定痕量锰（Mn）。虽然锰是人体健康必需的痕量金属，但长期接触锰往往会逐渐损害我们的神经系统。锰暴露的潜在来源使得监测各种样品基质中的浓度变得必要。我们和其他人之前的工作表明，阴极溶出伏安法是测量痕量锰的有效方法。对分析性能指标进行了表征和优化，在pH 5.5、0.2 M乙酸盐缓冲液中计算出的检测限（LOD）为16.3 nM（0.9 ppb）。此外，与电感耦合等离子体质谱（ICP-MS）“金标准”测量相比，我们成功验证了地表水中锰的测定，准确度约为90%，精密度>97%。最终，凭借稳定、准确和精确的电化学性能，这种铂传感器能够快速监测环境样品中的锰，如果与便携式仪器结合，还可能用于现场测量。
