Murtaza Ghulam, Faqah Anadil, Konowitz Nicholas, Lu Hannah, Kuruvilla Aneesh, Adhikari Sujeen
Department of Internal Medicine, Advocate Christ Medical Center, Oak Lawn, IL, USA.
Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
World J Oncol. 2017 Feb;8(1):18-19. doi: 10.14740/wjon1006e. Epub 2017 Feb 23.
Drug-induced acute pancreatitis is a rare cause of pancreatitis. We present a case of pancreatitis caused by pazopanib, a tyrosine kinase inhibitor used in the treatment of renal cell carcinoma. A 57-year-old male with no risk factors for pancreatitis and a past medical history of renal cell carcinoma who was being treated with pazopanib presented with epigastric pain with radiation to the back. Lipase was elevated to 7,960 units/L. Pazopanib was discontinued on arrival and his lipase levels decreased from 7,960 to 3,380 units/L one day after discontinuation. Abdominal pain resolved and patient tolerated a diet. This case illustrates the importance that medical professionals should be aware of acute pancreatitis as a rare but severe side effect of pazopanib and therefore should monitor and educate their patients accordingly.
药物性急性胰腺炎是胰腺炎的一种罕见病因。我们报告一例由帕唑帕尼引起的胰腺炎病例，帕唑帕尼是一种用于治疗肾细胞癌的酪氨酸激酶抑制剂。一名57岁男性，无胰腺炎危险因素，有肾细胞癌病史，正在接受帕唑帕尼治疗，出现上腹部疼痛并向后背部放射。脂肪酶升高至7960单位/升。入院时停用帕唑帕尼，停药一天后其脂肪酶水平从7960降至3380单位/升。腹痛缓解，患者能耐受饮食。该病例说明医疗专业人员应认识到急性胰腺炎是帕唑帕尼一种罕见但严重的副作用，因此应相应地对患者进行监测和教育。
