使用单克隆抗体快速诊断百日咳
Rapid diagnosis of whooping cough using monoclonal antibody.
作者信息
Boreland P C, Gillespie S H, Ashworth L A
机构信息
Department of Medical Microbiology, Waveney Hospital, Ballymena, Ireland.
出版信息
J Clin Pathol. 1988 May;41(5):573-5. doi: 10.1136/jcp.41.5.573.
A counterimmunoelectrophoresis (CIE) method for antigen detection using monoclonal antibody was assessed for its ability to aid in the rapid diagnosis of Bordetella pertussis in 59 patients. A positive diagnosis from a combination of results from tests of serum and urine was obtained in 51 (87%) of cases. For sera, CIE had a sensitivity of 85% and a specificity of 94%; for urine samples the sensitivity was 81% and a specificity of 100%. Antigen detection by CIE is simple to perform and yields results on the same day, thus allowing treatment to begin at an early stage.
评估了一种使用单克隆抗体进行抗原检测的对流免疫电泳（CIE）方法在协助快速诊断59例百日咳博德特氏菌患者方面的能力。51例（87%）病例通过血清和尿液检测结果相结合得出阳性诊断。对于血清，CIE的敏感性为85%，特异性为94%；对于尿液样本，敏感性为81%，特异性为100%。通过CIE进行抗原检测操作简单，当天即可得出结果，从而能够在早期开始治疗。
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