Garibaldi R A
Department of Medicine, University of Connecticut School of Medicine, Farmington 06032.
J Hosp Infect. 1988 Apr;11 Suppl B:5-9. doi: 10.1016/0195-6701(88)90149-1.
In a prospective, controlled, clinical trial, we found that preoperative showering and scrubbing with 4% chlorhexidine gluconate was more effective than povidone-iodine or triclocarban medicated soap in reducing skin colonization at the site of surgical incision. Mean log colony counts of the incision site were one half to one log lower for patients who showered with chlorhexidine compared to those who showered with the other regimens. No growth was observed on 43% of the post shower skin cultures from patients in the chlorhexidine group compared with 16% of the cultures from patients who had povidone-iodine showers and 5% of those from patients who used medicated soap and water. The frequency of positive intraoperative wound cultures was 4% with chlorhexidine, 9% with povidone-iodine and 14% with medicated soap and water. This study demonstrates that chlorhexidine gluconate is a more effective skin disinfectant than either povidone-iodine or triclocarban soap and water and that its use is associated with lower rates of intraoperative wound contamination.
在一项前瞻性、对照临床试验中，我们发现术前用4%葡萄糖酸氯己定沐浴和擦洗，在减少手术切口部位皮肤定植方面比聚维酮碘或三氯卡班药用皂更有效。与使用其他方案沐浴的患者相比，用氯己定沐浴的患者切口部位的平均对数菌落计数低一半至一个对数。氯己定组43%的患者沐浴后皮肤培养物未生长，而聚维酮碘沐浴患者的培养物为16%，使用药用皂和水的患者为5%。术中伤口培养阳性率氯己定组为4%，聚维酮碘组为9%，药用皂和水组为14%。这项研究表明，葡萄糖酸氯己定是一种比聚维酮碘或三氯卡班皂和水更有效的皮肤消毒剂，其使用与术中伤口污染率较低有关。
