a Department of Microbiology, School of Pharmacy , Kitasato University , Tokyo , Japan.
b The Institute of Microbiology, Department of Biology , ETH Zürich , Zurich , Switzerland.
Gut Microbes. 2018 Mar 4;9(2):179-187. doi: 10.1080/19490976.2017.1387344. Epub 2017 Oct 17.
In the inflamed gut, the bactericidal lectin RegIIIβ is massively produced by intestinal mucosa. RegIIIβ binds peptidoglycan and lipid A respectively, and thus can kill certain Gram-positive and Gram-negative bacteria, including the gut commensal microbiota and enteropathogenic bacteria. Considering the expression pattern and bactericidal activity, RegIIIβ is believed to be a host defense factor for protecting against the infection with enteropathogenic bacteria. However, it was poorly understood how RegIIIβ recognizes the target bacteria and kill them, and how RegIIIβ plays role(s) in infectious diarrhea. Therefore, our recent study has focused on RegIIIβ-target recognition, killing of Gram-negative bacteria, and host protective functions of RegIIIβ for infectious diarrhea inflicted by Salmonella Typhimurium. Here, we discuss novel insights into the protective role of RegIIIβ in infectious diarrhea, and propose avenues towards novel therapeutic interventions for Salmonella diarrhea.
在发炎的肠道中，肠道黏膜大量产生杀菌凝集素 RegIIIβ。RegIIIβ 分别与肽聚糖和脂多糖结合，因此可以杀死某些革兰氏阳性和革兰氏阴性细菌，包括肠道共生菌群和肠道致病菌。考虑到表达模式和杀菌活性，RegIIIβ 被认为是一种宿主防御因子，可防止肠道致病菌感染。然而，RegIIIβ 如何识别靶细菌并将其杀死，以及 RegIIIβ 在感染性腹泻中发挥何种作用尚不清楚。因此，我们最近的研究集中在 RegIIIβ 的靶标识别、对革兰氏阴性菌的杀伤作用以及 RegIIIβ 对鼠伤寒沙门氏菌感染性腹泻的宿主保护作用上。在这里，我们讨论了 RegIIIβ 在感染性腹泻中的保护作用的新见解，并为治疗沙门氏菌腹泻提出了新的治疗干预途径。
