Zheng Fang, Zhang Qinqin, Motulsky Elie H, de Oliveira Dias João Rafael, Chen Chieh-Li, Chu Zhongdi, Miller Andrew R, Feuer William, Gregori Giovanni, Kubach Sophie, Durbin Mary K, Wang Ruikang K, Rosenfeld Philip J
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China.
Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5098-5104. doi: 10.1167/iovs.17-22506.
We compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns.
Patients with neovascular age-related macular degeneration were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000). The scanning protocols included the 3 × 3, 6 × 6, 9 × 9, and 12 × 12 mm fields of view. Two groups were studied. Group 1 included small lesions contained within the 3 ( \times ) 3 mm scan, and Group 2 included larger lesions that were fully contained within the 6 ( \times ) 6 mm scan.
A total of 30 eyes of 26 patients were enrolled in Group 1 and 30 eyes of 25 patients were enrolled in Group 2. In Group 1, the automated mean lesion area measurements were 1.11 (SD = 0.78), 1.14 (SD = 0.80), and 1.27 (SD = 0.82) mm2 for the 3 ( \times ) 3, 6 ( \times ) 6, and 12 ( \times ) 12 mm scans, respectively (ANOVA P < 0.001; post hoc comparisons, P = 0.184, 3 ( \times ) 3 vs. 6 ( \times ) 6 mm; P < 0.001 for the other two pairs). In Group 2, the automated mean lesion area measurements were 5.43 (SD = 2.56), 5.53 (SD = 2.48), and 5.49 (SD = 2.65) mm2 for the 6 ( \times ) 6, 9 ( \times ) 9, and 12 ( \times ) 12 mm scans, respectively (ANOVA P = 0.435; post-hoc comparisons, P = 0.062, 6 ( \times ) 6 vs. 9 ( \times ) 9 mm; P = 0.553, 6 ( \times ) 6 vs. 12 ( \times ) 12 mm; P = 0.654, 9 ( \times ) 9 vs. 12 ( \times ) 12 mm).
The similarity in lesion area measurements across different scan patterns suggests that SS-OCTA imaging can be used to follow quantitatively the enlargement of choroidal neovascularization as the disease progresses.
我们比较了使用扫频源光学相干断层扫描血管造影（SS-OCTA）及放大扫描模式对同一新生血管病变进行成像时的面积测量结果。
使用100kHz的SS-OCTA仪器（PLEX Elite 9000）对患有新生血管性年龄相关性黄斑变性的患者进行成像。扫描方案包括3×3、6×6、9×9和12×12mm的视野。研究分为两组。第1组包括3×3mm扫描范围内的小病变，第2组包括完全在6×6mm扫描范围内的较大病变。
第1组共纳入26例患者的30只眼，第2组共纳入25例患者的30只眼。在第1组中，3×3、6×6和12×12mm扫描的自动平均病变面积测量值分别为1.11（标准差=0.78）、1.14（标准差=0.80）和1.27（标准差=0.82）mm²（方差分析P<0.001；事后比较，P=0.184，3×3与6×6mm；其他两对比较P<0.001）。在第2组中，6×6、9×9和12×12mm扫描的自动平均病变面积测量值分别为5.43（标准差=2.56）、5.53（标准差=2.48）和5.49（标准差=2.65）mm²（方差分析P=0.435；事后比较，P=0.062，6×6与9×9mm；P=0.553，6×6与12×12mm；P=0.654，9×9与12×12mm）。
不同扫描模式下病变面积测量结果的相似性表明，随着疾病进展，SS-OCTA成像可用于定量跟踪脉络膜新生血管的扩大。
